Safety and efficacy of responsive neurostimulation in the pediatric population: evidence from institutional review and patient-level meta-analysis

P Kerezoudis, A Gyftopoulos, AY Alexander… - Epilepsy & Behavior, 2022 - Elsevier
Background Responsive neurostimulation (RNS) is a novel technology for drug-resistant
epilepsy rising from bilateral hemispheres or eloquent cortex. Although recently approved …

Real-world preliminary experience with responsive neurostimulation in pediatric epilepsy: a multicenter retrospective observational study

Y Nagahama, TM Zervos, KK Murata, L Holman… - …, 2021 - journals.lww.com
Real-World Preliminary Experience With Responsive Neurostimu... : Neurosurgery Real-World
Preliminary Experience With Responsive Neurostimulation in Pediatric Epilepsy: A …

Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes

DN Anderson, CM Charlebois, EH Smith, TS Davis… - Brain, 2024 - academic.oup.com
In patients with drug-resistant epilepsy, electrical stimulation of the brain in response to
epileptiform activity can make seizures less frequent and debilitating. This therapy, known as …

Pathway of transient electronics towards connected biomedical applications

A Dutta, H Cheng - Nanoscale, 2023 - pubs.rsc.org
Transient electronic devices have shown promising applications in hardware security and
medical implants with diagnosing therapeutics capabilities since their inception. Control of …

Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery program

I Çavuş, JC Romanyshyn, JT Kennard… - Annals of …, 2016 - Wiley Online Library
Objective Aberrant glutamate and γ‐aminobutyric acid (GABA) neurotransmission contribute
to seizure generation and the epileptic state. However, whether levels of these …

Network connectivity predicts effectiveness of responsive neurostimulation in focal epilepsy

JM Fan, AT Lee, K Kudo, KG Ranasinghe… - Brain …, 2022 - academic.oup.com
Responsive neurostimulation is a promising treatment for drug-resistant focal epilepsy;
however, clinical outcomes are highly variable across individuals. The therapeutic …

[HTML][HTML] Responsive neurostimulation targeting the anterior, centromedian and pulvinar thalamic nuclei and the detection of electrographic seizures in pediatric and …

CP Beaudreault, CR Muh, A Naftchi… - Frontiers in Human …, 2022 - frontiersin.org
Background: Responsive neurostimulation (RNS System) has been utilized as a treatment
for intractable epilepsy. The RNS System delivers stimulation in response to detected …

Treatment of medically refractory seizures with responsive neurostimulation: 2 pediatric cases

MA Kokoszka, F Panov, M La Vega-Talbott… - Journal of …, 2018 - thejns.org
The responsive neurostimulation (RNS) system, an adjunctive treatment for
pharmacoresistant partial-onset seizures with 1 or 2 foci, has been available to patients …

Treatment for loss of control disorders

C Halpern, RC Malenka, H Wu - US Patent 11,642,528, 2023 - Google Patents
The present invention provides, inter alia, methods, apparatus, and systems useful for
ameliorating impulse control disorders known to be extremely disabling and common to …

Optogenetic stimulation reveals a latent tipping point in cortical networks during ictogenesis

RT Graham, RR Parrish, L Alberio, EL Johnson… - Brain, 2023 - academic.oup.com
Brain-state transitions are readily apparent from changes in brain rhythms, but are difficult to
predict, suggestive that the underlying cause is latent to passive recording methods. Among …