Abstract Research Methods and Procedures: Highfat (HF) diet feeding can induce obesity
and metabolic disorders in rodents that resemble the human metabolic syndrome. However …

The “fetal” or “early” origins of adult disease hypothesis was originally put forward by David
Barker and colleagues and stated that environmental factors, particularly nutrition, act in …

In type 2 diabetes, the β cells of the pancreas fail to produce enough insulin to meet the
body's demand, in part because of an acquired decrease in β-cell mass. In adults …

Abstract High-fat (HF)-diet rodent models have contributed significantly to the analysis of the
pathophysiology of the insulin resistance syndrome, but their phenotype varies distinctly …

When protein folding in the endoplasmic reticulum (ER) is disrupted by alterations in
homeostasis in the ER lumen, eucaryotic cells activate a series of signal transduction …

We have proposed the “glucolipotoxicity” hypothesis in which elevated free fatty acids
(FFAs) together with hyperglycemia are synergistic in causing islet β-cell damage because …

The endocrine pancreas undergoes major remodeling during neonatal development when
replication of differentiated β cells is the major mechanism by which β cell mass is regulated …

Patients with the metabolic syndrome are characterized by insulin resistance, obesity and a
predisposition to hypertension, dyslipidaemia, pancreatic β-cell dysfunction, type 2 diabetes …

Firmicutes and Bacteroidetes, 2 major phyla of gut microbiota, are involved in lipid and bile
acid metabolism to maintain systemic energy homeostasis in host. Recently, accumulating …

Obesity is typically associated with elevated levels of free fatty acids (FFAs) and is linked to
glucose intolerance and type 2 diabetes. FFAs exert divergent effects on insulin secretion …