Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

[HTML][HTML] AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

[HTML][HTML] Editor's choice–European Society for Vascular Surgery (ESVS) 2019 clinical practice guidelines on the management of abdominal aorto-iliac artery …

A Wanhainen, F Verzini, I Van Herzeele… - European Journal of …, 2019 - ejves.com
Members of this Guideline Writing Committee (GWC) were selected by the European Society
for Vascular Surgery (ESVS) to represent physicians involved in the management of patients …

[HTML][HTML] Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm

R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

Abdominal aortic aneurysms

N Sakalihasan, JB Michel, A Katsargyris… - Nature reviews Disease …, 2018 - nature.com
An abdominal aortic aneurysm (AAA) is a localized dilatation of the infrarenal aorta. AAA is a
multifactorial disease, and genetic and environmental factors play a part; smoking, male sex …

Lack of an effective drug therapy for abdominal aortic aneurysm

J Golledge, JV Moxon, TP Singh… - Journal of internal …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

Statins reduce abdominal aortic aneurysm growth, rupture, and perioperative mortality: a systematic review and meta‐analysis

K Salata, M Syed, MA Hussain… - Journal of the …, 2018 - Am Heart Assoc
Background There are no recognized pharmacological treatments for abdominal aortic
aneurysms (AAA), although statins are suggested to be beneficial. We sought to summarize …

JCS/JSCVS/JATS/JSVS 2020 guideline on diagnosis and treatment of aortic aneurysm and aortic dissection

H Ogino, O Iida, K Akutsu, Y Chiba, H Hayashi… - Circulation …, 2023 - jstage.jst.go.jp
Of the clinical practice guideline of the Japanese Circulation Society concerning aortic
diseases, the Guidelines on Diagnosis and Treatment of Aortic Dissection (first edition) were …

[HTML][HTML] Status of diagnosis and therapy of abdominal aortic aneurysms

J Lin, S Chen, Y Yao, M Yan - Frontiers in cardiovascular medicine, 2023 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are characterized by localized dilation of the abdominal
aorta. They are associated with several serious consequences, including compression of …

[HTML][HTML] Single-cell sequencing analysis and multiple machine learning methods identified G0S2 and HPSE as novel biomarkers for abdominal aortic aneurysm

T Xiong, XS Lv, GJ Wu, YX Guo, C Liu, FX Hou… - Frontiers In …, 2022 - frontiersin.org
Identifying biomarkers for abdominal aortic aneurysms (AAA) is key to understanding their
pathogenesis, developing novel targeted therapeutics, and possibly improving patients …