N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific
interest for decades due to its important medical applications. It also represents a nutritional …

Memantine, a partial antagonist of N-methyl-D-aspartate receptor (NMDAR), approved for
moderate to severe Alzheimer's disease (AD) treatment within the US and Europe under …

Background Emerging data suggest an important relationship between sleep and
Alzheimer's disease (AD), but how poor sleep promotes the development of AD remains …

Protein dyshomeostasis is the common mechanism of neurodegenerative diseases such as
Alzheimer's disease (AD). Aging is the key risk factor, as the capacity of the proteostasis …

Seizures in patients with Alzheimer's disease (AD) have been examined by many
investigators over the last several decades, and there are diverse opinions about their …

Amyloidopathy is one of the most prominent hallmarks of Alzheimer's disease (AD), the
leading cause of dementia worldwide, and is characterized by the accumulation of amyloid …

Senescence-accelerated OXYS rats are an experimental model of accelerated aging that
was established from Wistar stock via selection for susceptibility to cataractogenic effects of …

Key points High frequency (100–250 Hz) neuronal oscillations in the hippocampus, known
as sharp‐wave ripples (SWRs), synchronise the firing behaviour of groups of neurons and …

The significance of the selective enrichment in omega-3 essential fatty acids in
photoreceptors and synaptic membranes of the nervous system has remained, until recently …

Amyloid aggregation starts with the initial misfolding of peptide/protein precursors, with
subsequent structural rearrangement into oligomers and protofibrils; the latter eventually …