Profiling plasma alterations of extracellular vesicles in patients with acutely decompensated cirrhosis and bacterial infection

E Campello, A Zanetto, CM Radu, S Toffanin… - Liver …, 2024 - Wiley Online Library
Abstract Background Extracellular vesicles (EVs) modulate inflammation, coagulation and
vascular homeostasis in decompensated cirrhosis. Aim To characterize the profile of …

Cell-to-cell communications in alcohol-associated liver disease

NA Osna, A Eguchi, AE Feldstein, H Tsukamoto… - Frontiers in …, 2022 - frontiersin.org
This review covers some important new aspects of the alcohol-induced communications
between liver parenchymal and non-parenchymal cells leading to liver injury development …

DRAM1 increases the secretion of PKM2-enriched EVs from hepatocytes to promote macrophage activation and disease progression in ALD

J Tan, J Zhang, M Wang, Y Wang, M Dong, X Ma… - … Therapy-Nucleic Acids, 2022 - cell.com
DNA damage-regulated autophagy modulator 1 (DRAM1) could play important roles in
inflammation and hepatic apoptosis, while its roles in alcohol-related liver disease (ALD) …

Protein and miRNA profile of circulating extracellular vesicles in patients with primary sclerosing cholangitis

D Povero, M Tameda, A Eguchi, W Ren, J Kim… - Scientific reports, 2022 - nature.com
Primary sclerosing cholangitis (PSC) is an idiopathic and heterogenous cholestatic liver
disease characterized by chronic inflammation and fibrosis of the biliary tree. Currently, no …

Emerging Roles of extracellular vesicle-delivered circular RNAs in atherosclerosis

C Wen, B Li, L Nie, L Mao, Y Xia - Frontiers in Cell and …, 2022 - frontiersin.org
Atherosclerosis (AS) is universally defined as chronic vascular inflammation induced by
dyslipidaemia, obesity, hypertension, diabetes and other risk factors. Extracellular vesicles …

Proteomic analysis of small extracellular vesicles from the plasma of patients with hepatocellular carcinoma

W Dong, Z Xia, Z Chai, Z Qiu, X Wang, Z Yang… - World Journal of …, 2022 - Springer
Purpose Liver cancer is one of the most common tumors with the seventh-highest incidence
and the third-highest mortality. Many studies have shown that small extracellular vesicles …

Serum-derived miR-574-5p-containing exosomes contribute to liver fibrosis by activating hepatic stellate cells

X Zhou, Z Liang, S Qin, X Ruan, H Jiang - Molecular Biology Reports, 2022 - Springer
Aim To investigate the association of serum exosomes miR-574-5p with liver fibrosis, and
explore the effect and mechanism of serum exosomes on HSC activation. Materials and …

Serum extracellular vesicle‐derived ASS1 is a promising predictor for the occurrence of HEV‐ALF

Z Xiang, C Jiang, J Yang, L Huang… - Journal of Medical …, 2023 - Wiley Online Library
Abstract Development of biomarkers for predicting the occurrence of hepatitis E virus related‐
acute liver failure (HEV‐ALF) is conducive to prevention and early intervention. Serum …

Plasma Pattern of Extracellular Vesicles Isolated from Hepatitis C Virus Patients and Their Effects on Human Vascular Endothelial Cells

E Grossini, C Smirne, S Venkatesan, S Tonello… - International Journal of …, 2023 - mdpi.com
Hepatitis C virus (HCV) patients are at increased risk of cardiovascular disease (CVD). In
this study, we aimed to evaluate the role of extracellular vesicles (EVs) as pathogenic factors …

Extracellular vesicles as potential biomarkers and treatment options for liver failure: A systematic review up to March 2022

W Lu, H Tang, S Li, L Bai, Y Chen - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Extracellular vesicles (EVs) carrying functional cargoes are emerging as
biomarkers and treatment strategies in multiple liver diseases. Nevertheless, the potential of …