Green electrosynthesis of drug metabolites
In this concise review, the field of electrosynthesis (ES) as a green methodology for
understanding drug metabolites linked to toxicology is exemplified. ES describes the …
understanding drug metabolites linked to toxicology is exemplified. ES describes the …
Pathophysiology of drug hypersensitivity
AA Elzagallaai, MJ Rieder - British Journal of Clinical …, 2024 - Wiley Online Library
Drug hypersensitivity reactions (DHRs) are type B adverse drug reactions (ADRs)
traditionally defined as unpredictable, dose independent and not related to the drug …
traditionally defined as unpredictable, dose independent and not related to the drug …
Suppressing NLRP3 activation and PI3K/AKT/mTOR signaling ameliorates amiodarone-induced pulmonary fibrosis in rats: a possible protective role of nobiletin
MM El Tabaa, MM El Tabaa, RM Elgharabawy… - …, 2023 - Springer
Amiodarone (AMD), a medicine used to treat life-threatening arrhythmias, is frequently
linked to pulmonary fibrosis (PF). Despite the involvement of NLRP3 inflammasome and …
linked to pulmonary fibrosis (PF). Despite the involvement of NLRP3 inflammasome and …
Clozapine induces an acute proinflammatory response that is attenuated by inhibition of inflammasome signaling: implications for idiosyncratic drug-induced …
SC Sernoskie, AR Lobach, R Kato, A Jee… - Toxicological …, 2022 - academic.oup.com
Although clozapine is a highly efficacious schizophrenia treatment, it is under-prescribed
due to the risk of idiosyncratic drug-induced agranulocytosis (IDIAG). Clinical data indicate …
due to the risk of idiosyncratic drug-induced agranulocytosis (IDIAG). Clinical data indicate …
The role of myeloperoxidase in clozapine-induced inflammation: a mechanistic update for idiosyncratic drug-induced agranulocytosis
SC Sernoskie, A Jee, J Uetrecht - International Journal of Molecular …, 2023 - mdpi.com
The risk of idiosyncratic drug-induced agranulocytosis (IDIAG) markedly constrains the use
of clozapine, a neuroleptic with unparalleled efficacy. Most clozapine patients experience an …
of clozapine, a neuroleptic with unparalleled efficacy. Most clozapine patients experience an …
Mechanism of non-steroidal anti-androgen-induced liver injury: Reactive metabolites of flutamide and bicalutamide activate inflammasomes
Flutamide is a non-steroidal anti-androgen agent, which is mainly used for the treatment of
prostate cancer. Flutamide is known to cause severe adverse events, which includes …
prostate cancer. Flutamide is known to cause severe adverse events, which includes …
Involvement of extracellular vesicles in the proinflammatory response to clozapine: implications for clozapine-induced agranulocytosis
SC Sernoskie, É Bonneil, P Thibault, A Jee… - Journal of Pharmacology …, 2024 - ASPET
Most idiosyncratic drug reactions (IDRs) appear to be immune-mediated, but mechanistic
events preceding severe reaction onset remain poorly defined. Damage-associated …
events preceding severe reaction onset remain poorly defined. Damage-associated …
Insights gained into the injury mechanism of drug and herb induced liver injury in the hepatic microenvironment
X Zhang, Q Geng, L Lin, L Zhang, C Shi, B Liu, L Yan… - Toxicology, 2024 - Elsevier
Abstract Drug-Induced Liver Injury (DILI) and herb Induced Liver Injury (HILI) continues to
pose a substantial challenge in both clinical practice and drug development, representing a …
pose a substantial challenge in both clinical practice and drug development, representing a …
Regorafenib and reactive metabolite of sunitinib activate inflammasomes: Implications for multi tyrosine kinase inhibitor-Iiduced immune related adverse events
R Kato, Y Ijiri - Die Pharmazie-An International Journal of …, 2022 - ingentaconnect.com
Multi-targeted tyrosine kinase inhibitors have been developed for the treatment of various
cancers, but they are associated with a significant incidence of idiosyncratic drug reactions …
cancers, but they are associated with a significant incidence of idiosyncratic drug reactions …
Novel insights into molecular and cellular aspects of delayed drug hypersensitivity reactions
AA Elzagallaai, MJ Rieder - Expert Review of Clinical …, 2023 - Taylor & Francis
Introduction Delayed drug hypersensitivity reactions (DDHRs) represent a major health
problem. They are unpredictable and can cause life-long disability or even death. The …
problem. They are unpredictable and can cause life-long disability or even death. The …