The kidney is a model developmental system for understanding mesodermal patterning and
organogenesis, a process that requires regional specification along multiple body axes, the …

Cranial placodes (which include the adenohypophyseal, olfactory, lens, otic, lateral line,
profundal/trigeminal, and epibranchial placodes) give rise to many sense organs and …

Abstract Branchio-oto-renal (BOR)/branchio-otic (BO) syndrome is a rare disorder and
exhibits clinically heterogenous phenotypes, marked by abnormalities in the ear, branchial …

Renal tract malformations are congenital anomalies of the kidneys and/or lower urinary tract.
One challenging feature of these conditions is that they can present not only prenatally but …

In the past two decades, many studies have shown that sine oculis homeobox 1 (Six1) is a
powerful regulator of organogenesis and disease, with important roles in tumorigenesis; …

External ear abnormalities are frequent in newborns ranging from microtia to partial auricle
duplication. Little is known about the molecular mechanisms orchestrating external ear …

This article is the second in a 2-part series reviewing neuroimaging in childhood SNHL.
Previously, we discussed the clinical work-up of children with hearing impairment, the …

Abstract Branchio‐oto‐renal (BOR) syndrome is an autosomal dominant disorder
characterized by branchiogenic malformation, hearing loss and renal anomalies. The …

The neural crest (NC) cells and cranial placodes are two ectoderm-derived innovations in
vertebrates that led to the acquisition of a complex head structure required for a predatory …

BACKGROUND: Chronic kidney disease (CKD) has long been associated with hearing loss
in certain syndromes. Reported evidence to date has come from only small observational …