Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …

Abstract Glucose 6-phosphate dehydrogenase (G6PD) deficiency facilitates human
coronavirus infection due to glutathione depletion. G6PD deficiency may especially …

Cancer-associated fibroblasts (CAF) engage in tumor progression by promoting the ability of
cancer cells to undergo epithelial–mesenchymal transition (EMT), and also by enhancing …

Mechanistic target of rapamycin (mTOR, also known as mammalian target of rapamycin) is a
ubiquitous serine/threonine kinase that regulates cell growth, proliferation and survival …

The pentose phosphate pathway, one of the main antioxidant cellular defense systems, has
been related for a long time almost exclusively to its role as a provider of reducing power …

Oxidative stress is increased in systemic lupus erythematosus (SLE), and it contributes to
immune system dysregulation, abnormal activation and processing of cell-death signals …

Systemic lupus erythematosus (SLE) is an autoimmune disease mediated by pathogenic
autoantibodies directed against nucleoprotein complexes. Beyond the activation of …

The mechanistic target of rapamycin (mTOR) is a ubiquitous serine/threonine kinase, which
plays pivotal roles in integrating growth signals on a cellular level. To support proliferation …

Cancer cells experience an increase in oxidative stress. The pentose phosphate pathway
(PPP) is a major biochemical pathway that generates antioxidant NADPH. Here, we show …