Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM),
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …

Antibiotic-associated acute kidney injury (AA-AKI) is quite common, especially among
hospitalized patients; however, little is known about risk factors or mechanisms of why AA …

Antimicrobial resistance is a major global health challenge. As few new efficacious
antibiotics will become available in the near future, peptide antibiotics continue to be major …

Introduction MRSA is associated with causing a variety of infections including skin and skin
structure infections, catheter and device-related (eg central venous catheter, prosthetic heart …

Pediatric sepsis is a relevant cause of morbidity and mortality in this age group. Children are
affected differently in high and low-income countries. Antibiotics are crucial for the treatment …

Aims Several factors related to vancomycin‐induced nephrotoxicity (VIN) have not yet been
clarified. In the present study, we used Japanese big data to investigate novel factors and …

Background: The clinical significance of utilizing a vancomycin loading dose in critically ill
patients remains unclear. Objective: The main aim of this systematic review is to evaluate the …

Although the superiority of vancomycin dosing based on area under the concentration-time
curve (AUC 0-24) over that based on trough concentration has been reported, a dosing …

Purpose In the literature, the propriety of the meta-analytic treatment-effect produced by
combining randomized controlled trials (RCT) and non-randomized studies (NRS) is …

Introduction: The incidence of acute kidney injury (AKI) caused by vancomycin hydrochloride
(VCM) was reported to be 5–43%. VCM-induced AKI was reported to be more likely to occur …