Influenza antivirals and animal models

CJ Caceres, B Seibert, F Cargnin Faccin… - FEBS open …, 2022 - Wiley Online Library
Influenza A and B viruses are among the most prominent human respiratory pathogens.
About 3–5 million severe cases of influenza are associated with 300 000–650 000 deaths …

Airborne transmission of avian origin H9N2 influenza A viruses in mammals

CJ Cáceres, DS Rajao, DR Perez - Viruses, 2021 - mdpi.com
Influenza A viruses (IAV) are widespread viruses affecting avian and mammalian species
worldwide. IAVs from avian species can be transmitted to mammals including humans and …

Block the Spread: Barriers to Transmission of Influenza Viruses

V Le Sage, AC Lowen… - Annual Review of …, 2023 - annualreviews.org
Respiratory viruses, such as influenza viruses, cause significant morbidity and mortality
worldwide through seasonal epidemics and sporadic pandemics. Influenza viruses transmit …

Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges

O Terrier, M Si-Tahar, M Ducatez, C Chevalier… - PLoS …, 2021 - journals.plos.org
The development of safe and effective vaccines in a record time after the emergence of the
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a remarkable …

Zebrafish-based platform for emerging bio-contaminants and virus inactivation research

P Patel, A Nandi, SK Verma, N Kaushik, M Suar… - Science of The Total …, 2023 - Elsevier
Emerging bio-contaminants such as viruses have affected health and environment settings
of every country. Viruses are the minuscule entities resulting in severe contagious diseases …

Development of a monoclonal antibody PMab-292 against ferret podoplanin

N Goto, H Suzuki, T Tanaka, T Asano… - Monoclonal …, 2022 - liebertpub.com
Ferrets (Mustela putorius furo) have been used as small animal models to investigate severe
acute respiratory syndrome coronaviruses (SARS-CoV and SARS-CoV-2) infections …

In Vitro Modelling of Respiratory Virus Infections in Human Airway Epithelial Cells – A Systematic Review

LC Rijsbergen, LLA Van Dijk, MFM Engel… - Frontiers in …, 2021 - frontiersin.org
Respiratory tract infections (RTI) are a major cause of morbidity and mortality in humans. A
large number of RTIs is caused by viruses, often resulting in more severe disease in infants …

Pan-antiviral effects of a PIKfyve inhibitor on respiratory virus infection in human nasal epithelium and mice

J Baker, H Ombredane, L Daly, I Knowles… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Endocytosis, or internalization through endosomes, is a major cell entry mechanism used by
respiratory viruses. Phosphoinositide 5-kinase (PIKfyve) is a critical enzyme for the synthesis …

Vaccine Strategies to Elicit Mucosal Immunity

Y Song, F Mehl, SL Zeichner - Vaccines, 2024 - mdpi.com
Vaccines are essential tools to prevent infection and control transmission of infectious
diseases that threaten public health. Most infectious agents enter their hosts across mucosal …

Nonrespiratory sites of influenza‐associated disease: mechanisms and experimental systems for continued study

HM Froggatt, NS Heaton - The FEBS journal, 2022 - Wiley Online Library
The productive replication of human influenza viruses is almost exclusively restricted to cells
in the respiratory tract. However, a key aspect of the host response to viral infection is the …