Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
The role of PARP1 in neurodegenerative diseases and aging
K Mao, G Zhang - The FEBS journal, 2022 - Wiley Online Library
Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease
(PD), are characterized by progressive memory loss and motor impairment. Aging is a major …
(PD), are characterized by progressive memory loss and motor impairment. Aging is a major …
Targeting ROS-dependent AKT/GSK-3β/NF-κB and DJ-1/Nrf2 pathways by dapagliflozin attenuates neuronal injury and motor dysfunction in rotenone-induced …
Dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has emerged
as a promising neuroprotective agent in murine models of epilepsy and obesity-induced …
as a promising neuroprotective agent in murine models of epilepsy and obesity-induced …
[HTML][HTML] Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments
N Sekino, M Selim, A Shehadah - Journal of Neuroinflammation, 2022 - Springer
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis causes cerebral dysfunction in the short and long term and induces …
infection. Sepsis causes cerebral dysfunction in the short and long term and induces …
Glycogen synthase kinase-3 beta (GSK-3β) signaling: implications for Parkinson's disease
Abstract Glycogen synthase kinase 3 (GSK-3) dysregulation plays an important role in the
pathogenesis of numerous disorders, affecting the central nervous system (CNS) …
pathogenesis of numerous disorders, affecting the central nervous system (CNS) …
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways …
This paper reviews new drug targets in the treatment of depression and new drug
candidates to treat depression. Depression is characterized by aberrations in six intertwined …
candidates to treat depression. Depression is characterized by aberrations in six intertwined …
Inflammatory T helper 17 cells promote depression-like behavior in mice
BACKGROUND: Recognition of substantial immune-neural interactions is revising dogmas
about their insular actions and revealing that immune-neural interactions can substantially …
about their insular actions and revealing that immune-neural interactions can substantially …
[HTML][HTML] Glycogen synthase kinase-3 (GSK-3)-targeted therapy and imaging
MK Pandey, TR DeGrado - Theranostics, 2016 - ncbi.nlm.nih.gov
Abstract Glycogen synthase kinase-3 (GSK-3) is associated with various key biological
processes, including glucose regulation, apoptosis, protein synthesis, cell signaling, cellular …
processes, including glucose regulation, apoptosis, protein synthesis, cell signaling, cellular …
miR-98 reduces endothelial dysfunction by protecting blood–brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model
DL Bernstein, V Zuluaga-Ramirez… - Journal of Cerebral …, 2020 - journals.sagepub.com
Most neurological diseases, including stroke, lead to some degree of blood–brain barrier
(BBB) dysfunction. A significant portion of BBB injury is caused by inflammation, due to pro …
(BBB) dysfunction. A significant portion of BBB injury is caused by inflammation, due to pro …
Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior
Most psychiatric and neurological diseases are exacerbated by stress. Because this may
partially result from stress-induced inflammation, we examined factors involved in this stress …
partially result from stress-induced inflammation, we examined factors involved in this stress …