Inflammation contributes to mitochondrial dysfunction and neuronal apoptosis. The aim of
this study was to determine whether insulin-like growth factor-1 (IGF-1) alleviates …

OBJECTIVE Inflammation plays a key role in secondary brain damage following
intracerebral hemorrhage (ICH). Glycogen synthase kinase–3β (GSK-3β) plays a strong …

Eukaryotic organisms contain an enzyme family called poly (ADP-ribose) polymerases
(PARPs), which is responsible for the poly (ADP-ribosylation) of DNA-binding proteins …

Beaulieu, JM, Del'guidice, T., Sotnikova, TD, Lemasson, M., and Gainetdinov, RR (2011).
Beyond cAMP: the regulation of Akt and GSK3 by dopamine receptors. Front. Mol. Neurosci …

The Wnt canonical or the Wnt/β-catenin pathway has been implicated in the regulation of
several physiopathological pathways such as inflammation. Glucocorticoids (GCs) are …

Editor's Note: Lithium, an element that Mother Nature has put in some drinking water
sources, has been used for its curative powers for centuries. Today, it's given in capsule form …

The rising burden of unipolar depression along with its often related sleep disturbances, as
well as increasing rates of sleep restriction in modern society, make the search for an …

Targeting kinases linked to insulin resistance (IR) and inflammation may help in reducing
the risk of type 2 diabetes (T2D) and Alzheimer's disease (AD) in its early stages. This study …

Glycogen synthase kinase 3β (GSK3β) is known to control neuroinflammation, however the
status of GSK3β in multiple sclerosis, the most common inflammatory demyelinating disease …

Multiple sclerosis is a complex disease characterised by chronic inflammation,
demyelination and axonal pathology resulting in progressive neurological disabilities …