Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases

V Mittelheisser, V Gensbittel, L Bonati, W Li… - Nature …, 2024 - nature.com
Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Magnetic resonance elastography in the study of neurodegenerative diseases

Y Feng, MC Murphy, E Hojo, F Li… - Journal of Magnetic …, 2024 - Wiley Online Library
Neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease
(PD) present a major health burden to society. Changes in brain structure and cognition are …

Changes in tissue fluidity predict tumor aggressiveness in vivo

F Sauer, S Grosser, M Shahryari, A Hayn… - Advanced …, 2023 - Wiley Online Library
Cancer progression is caused by genetic changes and associated with various alterations in
cell properties, which also affect a tumor's mechanical state. While an increased stiffness …

A novel deep learning-driven approach for predicting the pelvis soft-tissue deformations toward a real-time interactive childbirth simulation

DH Nguyen-Le, A Ballit, TT Dao - Engineering Applications of Artificial …, 2023 - Elsevier
Background and objective Soft-tissue dynamics plays an essential role in the mechanical
functions of the human body. Numerical approaches using finite element modeling and …

MR elastography in cancer

J Guo, LJ Savic, KH Hillebrandt, I Sack - Investigative Radiology, 2023 - journals.lww.com
The mechanical traits of cancer include abnormally high solid stress as well as drastic and
spatially heterogeneous changes in intrinsic mechanical tissue properties. Whereas solid …

Stiffness pulsation of the human brain detected by non-invasive time-harmonic elastography

T Meyer, B Kreft, J Bergs, E Antes… - … in Bioengineering and …, 2023 - frontiersin.org
Introduction: Cerebral pulsation is a vital aspect of cerebral hemodynamics. Changes in
arterial pressure in response to cardiac pulsation cause cerebral pulsation, which is related …

Cortical matrix remodeling as a hallmark of relapsing–remitting neuroinflammation in MR elastography and quantitative MRI

RV Silva, AS Morr, H Herthum, SP Koch, S Mueller… - Acta …, 2024 - Springer
Multiple sclerosis (MS) is a chronic neuroinflammatory disease that involves both white and
gray matter. Although gray matter damage is a major contributor to disability in MS patients …

Photoacoustic remote sensing elastography

Y Yuan, X Wen, B Yuan, H Xin, B Fang, S Yang… - Optics Letters, 2023 - opg.optica.org
The mechanical properties of organisms are important indicators for clinical disputes and
disease monitoring, yet most existing elastography techniques are based on contact …

Multiparametric MRI for characterization of the tumour microenvironment

E Hoffmann, M Masthoff, WG Kunz… - Nature Reviews …, 2024 - nature.com
Our understanding of tumour biology has evolved over the past decades and cancer is now
viewed as a complex ecosystem with interactions between various cellular and non-cellular …

Tumor stiffness measurement at multifrequency MR elastography to predict lymphovascular space invasion in endometrial cancer

L Long, M Liu, X Deng, J Jin, M Cao, J Zhang, J Tao… - Radiology, 2024 - pubs.rsna.org
Background Pathologic lymphovascular space invasion (LVSI) is associated with poor
outcome in endometrial cancer. Its relationship with tumor stiffness, which can be measured …