Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in …

MO Welcome, D Dogo, NE Mastorakis - Inflammopharmacology, 2023 - Springer
Heart diseases and related complications constitute a leading cause of death and
socioeconomic threat worldwide. Despite intense efforts and research on the pathogenetic …

HSP90 modulates T2R bitter taste receptor nitric oxide production and innate immune responses in human airway epithelial cells and macrophages

RM Carey, BM Hariri, ND Adappa, JN Palmer, RJ Lee - Cells, 2022 - mdpi.com
Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various
cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two …

Covid-19 health care for afghan refugees as a minor ethnicity in iran; clinical differences and racial equality in health

N Kalani, N Hatami, S Ali, M Haghbeen… - … and Racial Equality …, 2021 - papers.ssrn.com
Objective: The aim of this research was to look at the clinical differences between Afghan
refugees and the Iranian community, as well as the evaluation of health-care inequalities …

The Bittersweet Symphony of COVID-19: Associations between TAS1Rs and TAS2R38 Genetic Variations and COVID-19 Symptoms

A Santin, B Spedicati, A Pecori, GG Nardone… - Life, 2024 - mdpi.com
The innate immune system is crucial in fighting SARS-CoV-2 infection, which is responsible
for coronavirus disease 2019 (COVID-19). Therefore, deepening our understanding of the …

TAS2R38 haplotypes, COVID-19 infection, and symptomatology: a cross-sectional analysis of data from the Canadian Longitudinal Study on Aging

T Meng, DE Nielsen - Scientific Reports, 2024 - nature.com
The TAS2R38 gene is well known for its function in bitter taste sensitivity, but evidence also
suggests a role in innate immunity. TAS2R38 may be relevant in coronavirus disease 2019 …

Bacillus amyloliquefaciens exopolysaccharide preparation induces glucagon-like peptide 1 secretion through the activation of bitter taste receptors

WW Sung, JH Tu, JS Yu, MZ Ulfa, JH Chang… - International Journal of …, 2021 - Elsevier
The exopolysaccharide preparation of Bacillus amyloliquefaciens amy-1 (EPS) regulates
glycemic levels and promotes glucagon-like peptide 1 (GLP-1) secretion in vivo and in vitro …

[PDF][PDF] Safety and Efficacy of Popular Iranian Herbal Cold Remedy for COVID-19: A Randomized Clinical Trial in Mild to Moderate COVID-19 Cases

S Abiri, AH Shiri, MSS Jahromi, E Rayatdoost… - J Med Chem …, 2023 - researchgate.net
Background: In traditional Persian medicine, an herbal cold remedy containing Sugarcane,
Black Myrobalan, and mastic is mentioned and it was being widely provided by grocery …

[HTML][HTML] TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in Primary Ciliary Dyskinesia

G Piatti, G Girotto, MP Concas, L Braga… - International Journal of …, 2024 - mdpi.com
Several chronic respiratory diseases could be risk factors for acquiring SARS-CoV-2
infection: among them, Primary Ciliary Dyskinesia (PCD) is a rare (about 1: 10.000) inherited …

Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patients

D Risso, D Carmagnola, G Morini, G Pellegrini… - Scientific reports, 2022 - nature.com
Bitter taste receptor TAS2R38 is expressed in the respiratory tract and can respond to
quorum-sensing molecules produced by pathogens, stimulating the release of nitric oxide …

Demographic history was a formative mechanism of the genetic structure for the taste receptor TAS2R16 in human populations inhabiting Africa's Sahel/Savannah …

I Kulichová, M Mouterde, MG Mokhtar… - American Journal of …, 2022 - Wiley Online Library
Objectives Mode of subsistence is an important factor influencing dietary habits and the
genetic structure of various populations through differential intensity of gene flow and …