Phage display is a molecular diversity technology that allows the presentation of large
peptide and protein libraries on the surface of filamentous phage. Phage display libraries …

S INCE THE INITIAL description of the Ki-l monoclonal antibody (MoAb) in 1982,'there has
been an overwhelming flood of information concerning the Hodgkm's disease@)-associated …

Chemokines such as CC motif ligand 5 (CCL5) regulate immune cell trafficking in the tumor
microenvironment (TME) and govern tumor development, making them promising targets for …

Immunosuppression may contribute to the progression of cancer. In this study we assessed
the structural and functional status of T cells from tumor specimens obtained from patients …

Single chain Fv chimeric receptors, or T-bodies, are described with intracellular sequences
comprising the costimulatory signaling domain of CD28 in series with the ζ-chain from the …

Construction of a bispecific single-chain antibody derivative is described that consists of two
different single-chain Fv fragments joined through a Gly-Ser linker. One specificity of the two …

The development of bispecific antibodies has attracted substantial interest, and many
different formats have been described. Those specifically containing an Fc part are mostly …

Bispecific antibodies usually do not occur in nature but are constructed by recombinant DNA
or cell-fusion technologies. Most are designed to recruit cytotoxic effector cells of the …

T cell activation is initiated upon binding of the T cell receptor (TCR)/CD3 complex to peptide–
major histocompatibility complexes (“signal 1”); activation is enhanced by engagement of a …

Bispecific Abs (bsAb) are promising immunological tools for the elimination of tumor cells in
minimal residual disease situations. In principle, they target an Ag on tumor cells and recruit …