Restoring susceptibility to aminoglycosides: identifying small molecule inhibitors of enzymatic inactivation
AJ Magaña, J Sklenicka, C Pinilla… - RSC Medicinal …, 2023 - pubs.rsc.org
Growing resistance to antimicrobial medicines is a critical health problem that must be
urgently addressed. Adding to the increasing number of patients that succumb to infections …
urgently addressed. Adding to the increasing number of patients that succumb to infections …
P53: A key player in diverse cellular processes including nuclear stress and ribosome biogenesis, highlighting potential therapeutic compounds
The tumor suppressor proteins are key transcription factors involved in the regulation of
various cellular processes, such as apoptosis, DNA repair, cell cycle, senescence, and …
various cellular processes, such as apoptosis, DNA repair, cell cycle, senescence, and …
Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons …
R Perriera, E Vitale, I Pibiri, PS Carollo, D Ricci… - International Journal of …, 2023 - mdpi.com
Nonsense mutations cause several genetic diseases such as cystic fibrosis, Duchenne
muscular dystrophy, β-thalassemia, and Shwachman–Diamond syndrome. These mutations …
muscular dystrophy, β-thalassemia, and Shwachman–Diamond syndrome. These mutations …
Human disease-causing mutations result in loss of leiomodin 2 through nonsense-mediated mRNA decay
CT Pappas, RM Mayfield, AE Dickerson, L Mi-Mi… - Plos …, 2024 - journals.plos.org
The leiomodin (Lmod) family of actin-binding proteins play a critical role in muscle function,
highlighted by the fact that mutations in all three family members (LMOD1-3) result in human …
highlighted by the fact that mutations in all three family members (LMOD1-3) result in human …
Anticodon Engineered Transfer RNAs (ACE-tRNAs) are a Platform Technology for Suppressing Nonsense Mutations
W Ko, JJ Porter, S Spelier, T Couch, I van der Windt… - bioRxiv, 2024 - biorxiv.org
Nonsense mutations arise from single nucleotide substitutions that result in premature
termination codons (PTCs). PTCs result in little to no full-length protein production and loss …
termination codons (PTCs). PTCs result in little to no full-length protein production and loss …
mRNA sequence features determine the efficiency of translation termination and association of the nonsense-mediated mRNA decay machinery with elongating …
K Mangkalaphiban - 2023 - repository.escholarship.umassmed …
Translation of mRNA into protein is terminated when the ribosome encounters one of the
three stop codons (UAA, UAG, and UGA) at the end of an open reading frame (ORF) …
three stop codons (UAA, UAG, and UGA) at the end of an open reading frame (ORF) …