[HTML][HTML] Crosstalk among circRNA/lncRNA, miRNA, and mRNA in osteoarthritis

H Kong, ML Sun, XA Zhang, XQ Wang - Frontiers in Cell and …, 2021 - frontiersin.org
Osteoarthritis (OA) is a joint disease that is pervasive in life, and the incidence and mortality
of OA are increasing, causing many adverse effects on people's life. Therefore, it is very vital …

[HTML][HTML] A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers

J Xu, X Wang, C Zhu, K Wang - Frontiers in cell and developmental …, 2022 - frontiersin.org
Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) is a lncRNA located
at the DLK1-MEG3 site of human chromosome 14q32. 3. The expression of MEG3 in various …

Therapeutic effects of bone marrow mesenchymal stem cells‐derived exosomes on osteoarthritis

Y Jin, M Xu, H Zhu, C Dong, J Ji, Y Liu… - Journal of cellular …, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) have shown chondroprotective effects in clinical models of
osteoarthritis (OA). However, effects of MSC‐derived exosomes on OA remain unclear. The …

[HTML][HTML] Interactions among lncRNA/circRNA, miRNA, and mRNA in musculoskeletal degenerative diseases

YL Zheng, G Song, JB Guo, X Su, YM Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
Musculoskeletal degenerative diseases (MSDDs) are pathological conditions that affect
muscle, bone, cartilage, joint and connective tissue, leading to physical and functional …

LncRNA SNHG7 alleviates IL-1β-induced osteoarthritis by inhibiting miR-214-5p-mediated PPARGC1B signaling pathways

J Xu, Y Pei, J Lu, X Liang, Y Li, J Wang… - International …, 2021 - Elsevier
Background As a common joint disease, osteoarthritis (OA) is the main cause of limited joint
mobility and disability. The role of lncRNAs in the regulation of OA is increasingly …

Dysregulation of lncRNAs in rheumatoid arthritis: biomarkers, pathogenesis and potential therapeutic targets

C Miao, L Bai, Y Yang, J Huang - Frontiers in Pharmacology, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology, mainly
manifested by persistent abnormal proliferation of fibroblast-like synoviocytes (FLSs) …

LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases

Z Li, J Gao, D Sun, Q Jiao, J Ma, W Cui, Y Lou… - Frontiers in …, 2022 - frontiersin.org
The prevalence and mortality rates of cardiovascular diseases are increasing, and new
treatment strategies are urgently needed. From the perspective of basic pathogenesis, the …

[HTML][HTML] LncRNA MEG3 regulates autophagy and pyroptosis via FOXO1 in pancreatic β-cells

X Li, C Bai, H Wang, T Wan, Y Li - Cellular signalling, 2022 - Elsevier
Diabetes mellitus (DM) is a chronic metabolic disease, and its exact pathogenesis remains
unclear. Autophagy and pyroptosis play an important role in pancreatic β-cells inflammation …

LncRNA MEG3 Protects Chondrocytes From IL-1β-Induced Inflammation via Regulating miR-9-5p/KLF4 Axis

Y Huang, D Chen, Z Yan, J Zhan, X Xue, X Pan… - Frontiers in …, 2021 - frontiersin.org
Background Osteoarthritis (OA) is a chronic degenerative disease of the joints characterized
by articular cartilage damage, subchondral bone remodeling, osteophyte formation, and …

SOX4-activated lncRNA MCM3AP-AS1 aggravates osteoarthritis progression by modulating miR-149-5p/Notch1 signaling

F Xu, QF Hu, J Li, CJ Shi, JW Luo, WC Tian, LW Pan - Cytokine, 2022 - Elsevier
Objective To clarify the expression and underlying network of long non-coding RNA
(lncRNA) MCM3AP-AS1 in osteoarthritis (OA). Methods Human articular cartilage samples …