There is convincing evidence that cellular prooxidant states—that is, increased
concentrations of active oxygen and organic peroxides and radicals—can promote initiated …

Tumor promoters provoke the elaboration of oxygen radicals by direct chemical generation
and through the indirect activation or alteration of cellular sources including membrane …

β-Lapachone (β-lap) induces apoptosis in various cancer cells, and its intracellular target
has recently been elucidated in breast cancer cells. Here we show that NAD (P) H: quinone …

In previous investigations into the mechanisms responsible for cell specificity in
hepatocarcinogenesis, we have demonstrated that O6-methylguanine accumulates in the …

Isomers of dinitrotoluene (DNT) are produced by the nitration of toluene. In 1980 nearly 8%
of the total toluene produced in the US was converted to DNT. The major use of DNT is in …

Background During the first few years of our study of mechanisms of chemical
carcinogenesis in the liver, we gradually became impressed by five considerations, each of …

I. Introduction"... on peut retrouver dans ce processus comme une sorte de sblection
pathologique qui amrne la Abbreviations: AAF, 2-acetylaminofluorene; ATPase, adenosine …

The present study examines the dose-response relationship for 2, 3, 7, 8-tetrachlorodibenzo-
p-dioxin (TCDD) promotion of histologic and biochemical parameters by using a two-stage …

Publisher Summary The investigation of nutritional and other environmentally derived
influences in animal experiments has established that vast arrays of compounds are …

Male Fisher 344 rats were solely fed a choline-supplemented diet for 65 to 105 weeks or a
choline-devoid diet for 24 to 102 weeks. Hepatocellular carcinomas developed in the latter …