The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

Translational regulation plays an important role in gene expression and function. Although
the transcriptional dynamics of mouse preimplantation embryos have been well …

Infertility affects~ 7% of couples of reproductive age with little change in incidence in the last
two decades. ART, as well as other interventions, have made major strides in correcting this …

In the United States, 36.5% of women between the ages of 20 and 39 years are obese. This
obesity results in not only metabolic disorders including type II diabetes and cardiovascular …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Pathways underlying mouse embryonic development have always informed efforts to derive,
maintain, and drive differentiation of human pluripotent stem cells. However, direct …

How the chromatin regulatory landscape in the inner cell mass cells is established from
differentially packaged sperm and egg genomes during preimplantation development is …

Abstract Poly (A)-tail-mediated post-transcriptional regulation of maternal mRNAs is vital in
the oocyte-to-embryo transition (OET). Nothing is known about poly (A) tail dynamics during …

The combined use of transcriptome and translatome as indicators of gene expression
profiles is usually more accurate than the use of transcriptomes alone, especially in cell …