Machine learning in drug design: Use of artificial intelligence to explore the chemical structure–biological activity relationship
The paper presents a comprehensive overview of the use of artificial intelligence (AI)
systems in drug design. Neural networks, which are one of the systems employed in AI, are …
systems in drug design. Neural networks, which are one of the systems employed in AI, are …
[HTML][HTML] Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data
J Menz, ME Götz, U Gündel, R Gürtler, K Herrmann… - Archives of …, 2023 - Springer
Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a
binary classification of chemical entities. For more than a decade, there has been a …
binary classification of chemical entities. For more than a decade, there has been a …
[HTML][HTML] Food-borne chemical carcinogens and the evidence for human cancer risk
Commonly consumed foods and beverages can contain chemicals with reported
carcinogenic activity in rodent models. Moreover, exposures to some of these substances …
carcinogenic activity in rodent models. Moreover, exposures to some of these substances …
[HTML][HTML] The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment
IMCM Rietjens, A Michael, HM Bolt, B Siméon… - Archives of …, 2022 - Springer
The “totality” of the human exposure is conceived to encompass life-associated endogenous
and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only …
and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only …
[HTML][HTML] Basic concepts of mixture toxicity and relevance for risk evaluation and regulation
D Bloch, P Diel, B Epe, M Hellwig, A Lampen… - Archives of …, 2023 - Springer
Exposure to multiple substances is a challenge for risk evaluation. Currently, there is an
ongoing debate if generic “mixture assessment/allocation factors”(MAF) should be …
ongoing debate if generic “mixture assessment/allocation factors”(MAF) should be …
A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment
KA Magurany, X Chang, R Clewell… - Toxicological …, 2023 - academic.oup.com
Globally, industries and regulatory authorities are faced with an urgent need to assess the
potential adverse effects of chemicals more efficiently by embracing new approach …
potential adverse effects of chemicals more efficiently by embracing new approach …
Lung cancer associated with combustion particles and fine particulate matter (PM2. 5)-The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon …
JA Holme, J Vondráček, M Machala… - Biochemical …, 2023 - Elsevier
Air pollution is the leading cause of lung cancer after tobacco smoking, contributing to 20%
of all lung cancer deaths. Increased risk associated with living near trafficked roads …
of all lung cancer deaths. Increased risk associated with living near trafficked roads …
[HTML][HTML] Phytochemicals as a complement to cancer chemotherapy: pharmacological modulation of the autophagy-apoptosis pathway
Bioactive plant derived compounds are important for a wide range of therapeutic
applications, and some display promising anticancer properties. Further evidence suggests …
applications, and some display promising anticancer properties. Further evidence suggests …
Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins
Arsenic is widely present in the environment and is associated with various population
health risks including cancers. Arsenic exposure at environmentally relevant levels …
health risks including cancers. Arsenic exposure at environmentally relevant levels …
A toxic friend: genotoxic and mutagenic activity of the probiotic strain Escherichia coli Nissle 1917
JP Nougayrède, CV Chagneau, JP Motta… - MSphere, 2021 - Am Soc Microbiol
The probiotic Escherichia coli strain Nissle 1917 (DSM 6601, Mutaflor), generally
considered beneficial and safe, has been used for a century to treat various intestinal …
considered beneficial and safe, has been used for a century to treat various intestinal …