Volatile organic compounds of lung cancer and possible biochemical pathways

M Hakim, YY Broza, O Barash, N Peled… - Chemical …, 2012 - ACS Publications
Lung cancer (LC) is the leading cause of cancer mortality, with more than 1 million deaths
worldwide every year. 1, 2 There are two major forms of LC disease: nonsmall cell LC …

Assessment, origin, and implementation of breath volatile cancer markers

H Haick, YY Broza, P Mochalski, V Ruzsanyi… - Chemical Society …, 2014 - pubs.rsc.org
A new non-invasive and potentially inexpensive frontier in the diagnosis of cancer relies on
the detection of volatile organic compounds (VOCs) in exhaled breath samples. Breath can …

Nanomaterial-based sensors for detection of disease by volatile organic compounds

YY Broza, H Haick - Nanomedicine, 2013 - Taylor & Francis
The importance of developing new diagnostic and detection technologies for the growing
number of clinical challenges is rising each year. Here, we present a concise, yet didactic …

Breathomics in lung disease

MP Van Der Schee, T Paff, P Brinkman… - Chest, 2015 - Elsevier
Volatile organic compounds (VOCs) are produced by virtually all metabolic processes of the
body. As such, they have potential to serve as noninvasive metabolic biomarkers. Since …

Nanoscale sensor technologies for disease detection via volatolomics

R Vishinkin, H Haick - Small, 2015 - Wiley Online Library
The detection of many diseases is missed because of delayed diagnoses or the low efficacy
of some treatments. This emphasizes the urgent need for inexpensive and minimally …

A nanomaterial-based breath test for short-term follow-up after lung tumor resection

YY Broza, R Kremer, U Tisch, A Gevorkyan… - … , Biology and Medicine, 2013 - Elsevier
In this case study, we demonstrate the feasibility of nanomaterial-based sensors for
identifying the breath-print of early-stage lung cancer (LC) and for short-term follow-up after …

Volatile fingerprints of cancer specific genetic mutations

N Peled, O Barash, U Tisch, R Ionescu… - … , Biology and Medicine, 2013 - Elsevier
We report on a new concept for profiling genetic mutations of (lung) cancer cells, based on
the detection of patterns of volatile organic compounds (VOCs) emitted from cell …

The scent fingerprint of hepatocarcinoma: in-vitro metastasis prediction with volatile organic compounds (VOCs)

H Amal, L Ding, B Liu, U Tisch, Z Xu, D Shi… - International journal …, 2012 - Taylor & Francis
Background Hepatocellular carcinoma (HCC) is a common and aggressive form of cancer.
Due to a high rate of postoperative recurrence, the prognosis for HCC is poor. Subclinical …

Detection of volatile organic compounds using microfabricated resonator array functionalized with supramolecular monolayers

Y Lu, Y Chang, N Tang, H Qu, J Liu… - … applied materials & …, 2015 - ACS Publications
This paper describes the detection of volatile organic compounds (VOCs) using an e-nose
type integrated microfabricated sensor array, in which each resonator is coated with different …

Recent progress in the design and clinical development of electronic-nose technologies

AD Wilson - Nanobiosensors in Disease Diagnosis, 2016 - Taylor & Francis
Electronic-nose (e-nose) devices are instruments designed to detect and discriminate
between precise complex gaseous mixtures of volatile organic compounds derived from …