[HTML][HTML] Astaxanthin and its effects in inflammatory responses and inflammation-associated diseases: recent advances and future directions

MX Chang, F Xiong - Molecules, 2020 - mdpi.com
Astaxanthin is a natural lipid-soluble and red-orange carotenoid. Due to its strong
antioxidant property, anti-inflammatory, anti-apoptotic, and immune modulation, astaxanthin …

Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials

A Donoso, J González-Durán, AA Muñoz… - Pharmacological …, 2021 - Elsevier
Astaxanthin is a natural C40 carotenoid with numerous reported biological functions, most of
them associated with its antioxidant and anti-inflammatory activity, standing out from other …

[HTML][HTML] Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases

Z Kohandel, T Farkhondeh, M Aschner… - Biomedicine & …, 2022 - Elsevier
Astaxanthin (AST) is a red pigmented carotenoid with significant antioxidant, anti-
inflammatory, anti-proliferative, and anti-apoptotic properties. In this study, we summarize …

Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration

S Fakhri, A Iranpanah, MM Gravandi, SZ Moradi… - Phytomedicine, 2021 - Elsevier
Background As common, progressive, and chronic causes of disability and death,
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …

Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals

F Abbaszadeh, S Fakhri, H Khan - Pharmacological research, 2020 - Elsevier
Spinal cord injury (SCI) is a neurological disorder associated with the loss of sensory and
motor function. Understanding the precise dysregulated signaling pathways, especially …

Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease

V Balendra, SK Singh - Open biology, 2021 - royalsocietypublishing.org
Oxidative stress, the imbalance of the antioxidant system, results in an accumulation of
neurotoxic proteins in Alzheimer's disease (AD). The antioxidant system is composed of …

[HTML][HTML] Anti-inflammatory and anticancer effects of microalgal carotenoids

J Ávila-Román, S García-Gil, A Rodríguez-Luna… - Marine Drugs, 2021 - mdpi.com
Acute inflammation is a key component of the immune system's response to pathogens, toxic
agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing …

[HTML][HTML] Three-dimensional bioprinting collagen/silk fibroin scaffold combined with neural stem cells promotes nerve regeneration after spinal cord injury

JP Jiang, XY Liu, F Zhao, X Zhu, XY Li… - Neural regeneration …, 2020 - journals.lww.com
Many studies have shown that bio-scaffolds have important value for promoting axonal
regeneration of injured spinal cord. Indeed, cell transplantation and bio-scaffold implantation …

Structures of astaxanthin and their consequences for therapeutic application

THP Brotosudarmo, L Limantara… - … Journal of Food …, 2020 - Wiley Online Library
Reactive oxygen species (ROS) are continuously generated as a by‐product of normal
aerobic metabolism. Elevated ROS formation leads to potential damage of biological …

[HTML][HTML] The neuroprotective effects of astaxanthin: therapeutic targets and clinical perspective

S Fakhri, I Yosifova Aneva, MH Farzaei… - Molecules, 2019 - mdpi.com
As the leading causes of human disability and mortality, neurological diseases affect
millions of people worldwide and are on the rise. Although the general roles of several …