Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over
the past 15 years. A multitude of different functions have been attributed to this adipokine. It …

Insulin resistance has long been associated with obesity. More than 40 years ago, Randle
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …

The white adipose organ is composed of both subcutaneous and several intra-abdominal
depots. Excess abdominal adiposity is a major risk factor for metabolic disease in rodents …

Background & Aims The prevalence of nonalcoholic fatty liver disease (NAFLD) has
increased with the obesity pandemic. We analyzed the transcriptional profiles of …

The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases
inflammation and promotes cell survival. No unifying mechanism has yet explained how …

Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD)
organelles by professional storage cells called adipocytes. These lipids are mobilized …

Adipose tissue is now recognized as an important endocrine organ, capable of secreting a
large number of endocrine factors which regulate a wide variety of physiological functions …

Obesity and its associated metabolic syndromes represent a growing global challenge, yet
mechanistic understanding of this pathology and current therapeutics are unsatisfactory. We …

Adipose tissue represents a critical component in healthy energy homeostasis. It fulfills
important roles in whole‐body lipid handling, serves as the body's major energy storage …

While the link between obesity and type 2 diabetes is clear on an epidemiological level, the
underlying mechanism linking these two common disorders is not as clearly understood …