Insulin sensitivity: modulation by nutrients and inflammation

S Schenk, M Saberi, JM Olefsky - The Journal of clinical …, 2008 - Am Soc Clin Investig
Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential …

Adiponectin receptor as a key player in healthy longevity and obesity-related diseases

T Yamauchi, T Kadowaki - Cell metabolism, 2013 - cell.com
Adiponectin is a fat-derived hormone whose reduction plays central roles in obesity-linked
diseases including insulin resistance/type 2 diabetes and atherosclerosis. The cloning of …

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

C Postic, J Girard - The Journal of clinical investigation, 2008 - Am Soc Clin Investig
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and
type 2 diabetes. NAFLD represents a large spectrum of diseases ranging from (i) fatty liver …

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

CM Kusminski, WL Holland, K Sun, J Park… - Nature medicine, 2012 - nature.com
We examined mouse models with altered adipocyte expression of mitoNEET, a protein
residing in the mitochondrial outer membrane, to probe its impact on mitochondrial function …

[图书][B] Food lipids: chemistry, nutrition, and biotechnology

CC Akoh - 2017 - taylorfrancis.com
Maintaining the high standards that made the previous editions such well-respected and
widely used references, Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition …

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism

H Cao, K Gerhold, JR Mayers, MM Wiest, SM Watkins… - Cell, 2008 - cell.com
Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin
action and glucose metabolism. Utilizing quantitative lipidomic analyses and mice deficient …

Adipogenesis

K Sarjeant, JM Stephens - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
Adipose tissue is an important site for lipid storage, energy homeostasis, and whole-body
insulin sensitivity. It is important to understand the mechanisms involved in adipose tissue …

Inflammation as a link between obesity and metabolic syndrome

F Emanuela, M Grazia, DR Marco… - Journal of nutrition …, 2012 - Wiley Online Library
The metabolic syndrome is a complex of clinical features leading to an increased risk for
cardiovascular disease and type 2 diabetes mellitus in both sexes. Visceral obesity and …

Lipid homeostasis, lipotoxicity and the metabolic syndrome

RH Unger, GO Clark, PE Scherer, L Orci - Biochimica et Biophysica Acta …, 2010 - Elsevier
In the 20th century industrialized nations have become afflicted with an unprecedented
pandemic of increased adiposity. In the United States, the epicenter of the epidemic, over …

Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism

KG Kumar, JL Trevaskis, DD Lam, GM Sutton, RA Koza… - Cell metabolism, 2008 - cell.com
Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated.
Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis …