Purpose: Trials of adoptive natural killer (NK)-cell immunotherapy for hematologic
malignancies have thus far shown only marginal effects, despite the potent in vitro antitumor …

Natural killer (NK) cells contribute to the development of obesity-associated insulin
resistance. We demonstrate that in mice obesity promotes expansion of a distinct, interleukin …

Stem cells are characterized by self-renew and multipotent differentiation abilities. Besides
their roles in cell compensation, stem cells are also rich sources of growth factors, cytokines …

TGF-β is a potent immunosuppressive cytokine that severely affects the function of NK cells.
Tumor cells can take advantage of this ability, enriching their surrounding microenvironment …

Human liver contains an Eomes hi population of NK cells that is not present in the blood. In
this study, we show that these cells are characterized by a molecular signature that mediates …

NK cells have potent antitumor capacity. They are enriched in the human liver, with a large
subset specialized for tissue-residence. The potential for liver-resident versus liver …

Highlights•NK cells and unconventional T cells are robustly activated in SARS-CoV-2
infection.•Both populations of cells also home to lung tissue during acute infection.•Severe …

The lung offers one of the largest exchange surfaces of the individual with the elements of
the environment. As a place of important interactions between self and non-self, the lung is …

Human lung tissue-resident NK cells (trNK cells) are likely to play an important role in host
responses towards viral infections, inflammatory conditions and cancer. However, detailed …

Combinations of KIR and HLA genes associate with pregnancy complications as well as
with many other clinical scenarios. Understanding how certain KIR and HLA genes influence …