Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …

Posttranslational histone modifications define chromatin structure and function. In recent
years, a number of studies have characterized many of the enzymatic activities and diverse …

Genetic and epigenetic factors are of great importance in cardiovascular biology and
disease. Tobacco-smoking, one of the most important cardiovascular risk factors, is itself …

Background Social and economic factors are important predictors of health and of
recognized importance for health systems. However, machine learning, used elsewhere in …

Methylation levels have been shown to change with age at sites across the human genome.
Change at some of these sites is so consistent across individuals that it can be used as an …

Metabolomics is becoming feasible for population-scale studies of human disease. In this
review, we survey epidemiological studies that leverage metabolomics and multi-omics to …

The regulation of spermatogonial stem cell (SSC) proliferation and self-renewal is a complex
process. Several studies on the microRNA regulation of mammalian spermatogenesis have …

Background Genome-wide studies identified pan-cancer genes and shared biological
networks affected by epigenetic dysregulation among diverse tumor entities. Here, we …

Epigenetic modifications of DNA, such as cytosine methylation are differentially abundant in
diseases such as cancer. A goal for clinical research is finding sites that are differentially …

Purpose: To introduce current and emerging approaches that are being utilized in the field of
genomics so the reader can conceptually evaluate the literature and appreciate how these …