Multidrug resistance (MDR) poses a significant obstacle to effective cancer treatment, and
the tumor microenvironment (TME) is crucial for MDR development and reversal. The TME …

Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a high
mortality rate. It is regarded as a significant public health issue because of its complicated …

Accumulating evidence suggests the minority of patients with advanced pancreatic ductal
adenocarcinoma (PDAC) that have microsatellite instability high (MSI-H) can benefit from …

Background Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated
mortality in the world. However, the anticancer effects of aucubin against HCC have yet to be …

The liver maintains a balance between immune tolerance and activation in its role as a
filtration system. Chronic inflammation disrupts this immune microenvironment, thereby …

Simple Summary Hepatocellular Carcinoma (HCC) is a common and aggressive cancer
with limited treatment options. Approximately half of all patients with HCC receive systemic …

The emergence of immune checkpoint inhibitors (ICIs) has provided a new treatment option
for patients with hepatocellular carcinoma (HCC). However, further evaluation is needed for …

Background Previous studies have demonstrated that PANoptosis is strongly correlated with
cancer immunity and progression. This study aimed to develop a PANoptosis-related …

Hepatocellular carcinoma (HCC), one of the leading causes of cancer‑related mortality
worldwide, is challenging to identify in its early stages and prone to metastasis, and the …

Background Liquid-liquid phase separation (LLPS) enhances oncogenic signaling
pathways and advances cancer progression, and has been proposed as a promising cancer …