Berberine (BBR), an isoquinoline alkaloid extracted from Coptidis Rhizoma, has a long
history of treating dysentery in the clinic. Over the past two decades, the polytrophic …

Breast cancer (BC) is a common malignancy that mainly occurred in women and it has
become the most diagnosed cancer annually since 2020. Berberine (BBR), an alkaloid …

Colorectal cancer (CRC) is one of the most deaths causing diseases worldwide. Several risk
factors including hormones like insulin and insulin like growth factors (eg, IGF-1) have been …

Introduction: Berberine is a natural isoquinoline alkaloid with anti-cancer properties.
Nevertheless, the underlying mechanism of its action in human colorectal cancer (CRC) has …

Colorectal cancer (CRC) is one of the most identified and deadly malignancies worldwide. It
presents a serious challenge due to its quick growth, which finally culminates in severe …

Premature ovarian insufficiency (POI) is a clinical syndrome that declines ovarian function in
women. Berberine (BBR) is a compound with anti-inflammatory, antioxidant, and anti …

Background Berberine is a quaternary isoquinoline alkaloid that possesses a significant
therapeutic effect on a variety of cancers. However, due to poor bioavailability, an increased …

Simple Summary Colorectal cancer (CRC) incidence is increasing worldwide and
represents an important health problem. Therapy failure and progression to metastatic …

Chemotherapy-induced peripheral neuropathy (CIPN) often develops in patients with cancer
treated with commonly used anti-cancer drugs. The symptoms of CIPN can occur acutely …

Purpose Invasion of the pancreas and/or duodenum with/without neighboring organs by
locally advanced right colon cancer (LARCC) is a very rare clinical phenomenon that is …