Pyoderma gangrenosum is a rare inflammatory skin disease classified within the group of
neutrophilic dermatoses and clinically characterized by painful, rapidly evolving cutaneous …

Since the late 1990s, tumor necrosis factor alpha (TNF-α) inhibitors (anti-TNFs) have
revolutionized the therapy of immune-mediated inflammatory diseases (IMIDs) affecting the …

Inflammatory bowel diseases (IBDs) may be associated with extra-intestinal manifestations.
Among these, mucocutaneous manifestations are relatively frequent, often difficult to …

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a posttranslational regulator of the
LDL receptor (LDLR). Recent studies have proposed a role for PCSK9 in regulating immune …

Abstract Purpose of Review Neutrophilic dermatoses are defined by the presence of a sterile
neutrophilic infiltrate on histopathology. This review focuses on the pathogenesis …

Monoclonal gammopathy associated with dermatological manifestations are a well-
recognized complication. These skin disorders can be associated with infiltration and …

Females are generally more affected by autoimmune diseases, a fact that underlines the
relationship with pregnancy and the safety of anti-rheumatic drugs in pregnancy and …

Pyoderma gangrenosum (PG) is a rare autoinflammatory ulcerative neutrophilic skin
disease. Its clinical presentation is a rapidly progressing painful skin ulcer with ill-defined …

Pyoderma gangrenosum is a rare neutrophilic dermatosis that leads to exceedingly painful
ulcerations of the skin. Although the exact pathogenesis is not yet fully understood, various …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease typically involving the
gastrointestinal tract but not limited to it. IBD can be subdivided into Crohn's disease (CD) …