Advances and prospects in the treatment of pancreatic cancer

H Duan, L Li, S He - International journal of nanomedicine, 2023 - Taylor & Francis
Pancreatic cancer is a highly malignant and incurable disease, characterized by its
aggressive nature and high fatality rate. The most common type is pancreatic ductal …

Nanotechnology-based approaches overcome lung cancer drug resistance through diagnosis and treatment

J Li, L Zhu, HF Kwok - Drug Resistance Updates, 2023 - Elsevier
Lung cancer continues to be a malignant tumor with high mortality. Two obstacles interfere
with curative therapy of lung cancer:(i) poor diagnosis at the early stages, as symptoms are …

Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance

A Stigliani, R Ialchina, J Yao, D Czaplinska, Y Dai… - Cell Reports, 2024 - cell.com
Harsh environments in poorly perfused tumor regions may select for traits driving cancer
aggressiveness. Here, we investigated whether tumor acidosis interacts with driver …

[HTML][HTML] Cancer-associated fibroblasts mediate resistance to anti-EGFR therapies in cancer

S Dai, Y Liu, Z Liu, R Li, F Luo, Y Li, L Dai… - Pharmacological …, 2024 - Elsevier
Over the last decade, epidermal growth factor receptor (EGFR)-targeted therapies have
transformed the treatment landscape for patients with advanced solid tumors. Despite these …

LARP4B promotes hepatocellular carcinoma progression and impairs sorafenib efficacy by activating SPINK1-mediated EGFR pathway

C Wang, R Dong, F Yang, L Zheng, Y Liu, Y Yan… - Cell Death …, 2024 - nature.com
La-related proteins (LARPs) regulate gene expression by binding to RNAs and exhibit
critical effects on disease progression, including tumors. However, the role of LARP4B and …

Role and potential therapeutic value of histone methyltransferases in drug resistance mechanisms in lung cancer

L Zhang, X Zhang, Y Shi, Y Ni, J Fei, Z Jin, W Li… - Frontiers in …, 2024 - frontiersin.org
Lung cancer, ranking second globally in both incidence and high mortality among common
malignant tumors, presents a significant challenge with frequent occurrences of drug …

Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance in a p53-dependent manner

A Stigliani, R Ialchina, J Yao, D Czaplinska, Y Dai… - bioRxiv, 2023 - biorxiv.org
The harsh environments in poorly perfused tumor regions have been proposed to select for
traits that may drive cancer aggressiveness. Here, we tested the hypothesis that tumor …

Analysis of clinical features, prognosis and potential target genes of refractory meningioma--Research based on multiple databases

S Li, M Li, K Zhu, S Zhang - 2023 - researchsquare.com
Objective: Analyzing SEER database data on malignant meningiomas, we explored high-
risk factors for refractory meningiomas (RMs). Additionally, we analyzed GEO database …