The bone marrow microenvironment, also known as the bone marrow niche, is a complex
network of cell types and acellular factors that supports normal hematopoiesis. For many …

Metabolic reprogramming, carried out by cancer cells to rapidly adapt to stress such as
hypoxia and limited nutrient conditions, is an emerging concepts in tumor biology, and is …

Background Approximately 70% of lower-grade gliomas harbor isocitrate dehydrogenase 1
(IDH1) mutations, resulting in the accumulation of oncometabolite D-2-hydroxyglutarate (D-2 …

Mutations in the isocitrate dehydrogenase (IDH) 1 gene are commonly found in human
glioma, with the majority of low-grade gliomas harboring a recurrent point mutation (IDH1 …

New drugs introduced to the market every year represent privileged structures for particular
biological targets. These new chemical entities (NCEs) provide insight into molecular …

Forkhead box (FOX) proteins are a group of transcriptional factors implicated in different
cellular functions such as differentiation, proliferation and senescence. A growing number of …

Acute myeloid leukaemia (AML) is the most common form of acute leukaemia in adults, with
increasing incidence with age and a generally poor prognosis. Almost 20% of AML patients …

Malignant tumors have become a significant public health problem that severely threatens
human health. Drug-targeting therapy is essential for tumor therapy, along with surgery and …

Background: Genomic sequencing technologies have identified isocitrate dehydrogenase
(IDH) mutations in haematological malignancies. The prognostic implications of somatic IDH …

Malignant cells possess a unique metabolic machinery to endure unobstructed cell survival.
It comprises several levels of metabolic networking consisting of 1) upregulated expression …