[HTML][HTML] Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis
The bone marrow microenvironment, also known as the bone marrow niche, is a complex
network of cell types and acellular factors that supports normal hematopoiesis. For many …
network of cell types and acellular factors that supports normal hematopoiesis. For many …
Modulation of mitochondrial metabolic reprogramming and oxidative stress to overcome chemoresistance in cancer
Metabolic reprogramming, carried out by cancer cells to rapidly adapt to stress such as
hypoxia and limited nutrient conditions, is an emerging concepts in tumor biology, and is …
hypoxia and limited nutrient conditions, is an emerging concepts in tumor biology, and is …
The first-in-human phase I study of a brain-penetrant mutant IDH1 inhibitor DS-1001 in patients with recurrent or progressive IDH1-mutant gliomas
A Natsume, Y Arakawa, Y Narita, K Sugiyama… - Neuro …, 2023 - academic.oup.com
Background Approximately 70% of lower-grade gliomas harbor isocitrate dehydrogenase 1
(IDH1) mutations, resulting in the accumulation of oncometabolite D-2-hydroxyglutarate (D-2 …
(IDH1) mutations, resulting in the accumulation of oncometabolite D-2-hydroxyglutarate (D-2 …
Novel IDH1-targeted glioma therapies
G Karpel-Massler, TTT Nguyen, E Shang, MD Siegelin - CNS drugs, 2019 - Springer
Mutations in the isocitrate dehydrogenase (IDH) 1 gene are commonly found in human
glioma, with the majority of low-grade gliomas harboring a recurrent point mutation (IDH1 …
glioma, with the majority of low-grade gliomas harboring a recurrent point mutation (IDH1 …
Synthetic approaches to new drugs approved during 2018
AC Flick, CA Leverett, HX Ding, E McInturff… - Journal of medicinal …, 2020 - ACS Publications
New drugs introduced to the market every year represent privileged structures for particular
biological targets. These new chemical entities (NCEs) provide insight into molecular …
biological targets. These new chemical entities (NCEs) provide insight into molecular …
The role of forkhead box proteins in acute myeloid leukemia
C Gurnari, G Falconi, E De Bellis, MT Voso, E Fabiani - Cancers, 2019 - mdpi.com
Forkhead box (FOX) proteins are a group of transcriptional factors implicated in different
cellular functions such as differentiation, proliferation and senescence. A growing number of …
cellular functions such as differentiation, proliferation and senescence. A growing number of …
[HTML][HTML] Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China
Z Wang, Z Zhang, Y Li, L Sun, D Peng, D Du… - … Pharmaceutica Sinica B, 2021 - Elsevier
Acute myeloid leukaemia (AML) is the most common form of acute leukaemia in adults, with
increasing incidence with age and a generally poor prognosis. Almost 20% of AML patients …
increasing incidence with age and a generally poor prognosis. Almost 20% of AML patients …
Small-Molecule Anti-Cancer Drugs From 2016 to 2020: Synthesis and Clinical Application
L Wang, R Li, C Song, Y Chen… - Natural Product …, 2021 - journals.sagepub.com
Malignant tumors have become a significant public health problem that severely threatens
human health. Drug-targeting therapy is essential for tumor therapy, along with surgery and …
human health. Drug-targeting therapy is essential for tumor therapy, along with surgery and …
IDH1 Mutation Is an Independent Inferior Prognostic Indicator for Patients with Myelodysplastic Syndromes
N Wang, F Wang, N Shan, X Sui, H Xu - Acta Haematologica, 2017 - karger.com
Background: Genomic sequencing technologies have identified isocitrate dehydrogenase
(IDH) mutations in haematological malignancies. The prognostic implications of somatic IDH …
(IDH) mutations in haematological malignancies. The prognostic implications of somatic IDH …
Diverse stakeholders of tumor metabolism: an appraisal of the emerging approach of multifaceted metabolic targeting by 3-bromopyruvate
Malignant cells possess a unique metabolic machinery to endure unobstructed cell survival.
It comprises several levels of metabolic networking consisting of 1) upregulated expression …
It comprises several levels of metabolic networking consisting of 1) upregulated expression …