Meningioma: a review of epidemiology, pathology, diagnosis, treatment, and future directions

C Ogasawara, BD Philbrick, DC Adamson - Biomedicines, 2021 - mdpi.com
Meningiomas are the most common intracranial tumor, making up more than a third of all
primary central nervous system (CNS) tumors. They are mostly benign tumors that can be …

Tumor infiltrating immune cells in gliomas and meningiomas

P Domingues, M González-Tablas, Á Otero… - Brain, behavior, and …, 2016 - Elsevier
Tumor-infiltrating immune cells are part of a complex microenvironment that promotes and/or
regulates tumor development and growth. Depending on the type of cells and their …

Integrated molecular-morphologic meningioma classification: a multicenter retrospective analysis, retrospectively and prospectively validated

SLN Maas, D Stichel, T Hielscher, P Sievers… - Journal of clinical …, 2021 - ascopubs.org
PURPOSE Meningiomas are the most frequent primary intracranial tumors. Patient outcome
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …

A molecularly integrated grade for meningioma

J Driver, SE Hoffman, S Tavakol, E Woodward… - Neuro …, 2022 - academic.oup.com
Background Meningiomas are the most common primary intracranial tumor in adults.
Clinical care is currently guided by the World Health Organization (WHO) grade assigned to …

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

F Sahm, D Schrimpf, D Stichel, DTW Jones… - The lancet …, 2017 - thelancet.com
Background The WHO classification of brain tumours describes 15 subtypes of meningioma.
Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III …

TERT promoter mutations and risk of recurrence in meningioma

F Sahm, D Schrimpf, A Olar, C Koelsche… - Journal of the …, 2016 - academic.oup.com
Abstract The World Health Organization (WHO) classification and grading system attempts to
predict the clinical course of meningiomas based on morphological parameters. However …

Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma

M Abedalthagafi, WL Bi, AA Aizer, PH Merrill… - Neuro …, 2016 - academic.oup.com
Background Meningiomas are the most common primary intracranial tumor in adults.
Identification of SMO and AKT1 mutations in meningiomas has raised the possibility of …

Intermediate-risk meningioma: initial outcomes from NRG Oncology RTOG 0539

L Rogers, P Zhang, MA Vogelbaum, A Perry… - Journal of …, 2017 - thejns.org
OBJECTIVE This is the first clinical outcomes report of NRG Oncology RTOG 0539, detailing
the primary endpoint, 3-year progression-free survival (PFS), compared with a predefined …

Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas

GM Shankar, M Abedalthagafi, RA Vaubel… - Neuro …, 2017 - academic.oup.com
Background. Patients with meningiomas have widely divergent clinical courses. Some
entirely recover following surgery alone, while others have relentless tumor recurrences …

Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma

A Olar, KM Wani, CD Wilson, G Zadeh, F DeMonte… - Acta …, 2017 - Springer
Meningioma is the most common primary brain tumor and carries a substantial risk of local
recurrence. Methylation profiles of meningioma and their clinical implications are not well …