Methotrexate (MTX) is a folate analogue originally synthesised in the 1940s and designed to
inhibit dihydrofolate reductase. 1 Reduced folate (tetrahydrofolate) is the proximal single …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their
mechanisms are poorly understood. Here, 19F NMR is used to delineate the effects of …

Whole‐hemisphere sections from six subjects were used in a quantitative autoradiographic
study to characterize and to investigate the distribution of adenosine receptors, using [3H] …

The parathyroid hormone (PTH) and its related peptide (PTHrP) activate PTH receptor
(PTHR) signaling, but only the PTH sustains GS-mediated adenosine 3′, 5′-cyclic …

The effects of a mixture of oligo‐and polydeoxyribonucleotides (PDRN) on the growth and
protein secretion of cultured human skin fibroblasts were investigated. Both intact and …

2 '-C-Methyl analogues of selective adenosine receptor agonists such as (R)-PIA, CPA,
CCPA, NECA, and IB-MECA were synthesized in order to further investigate the subdomain …

Epoxyeicosatrienoic acids (EETs) are important regulators of vascular tone and
homeostasis. Whether they initiate signaling through membrane receptors is unclear. We …

The chemokine receptor CX3CR1 has been implicated as an attractive therapeutic target in
several diseases, including atherosclerosis and diabetes. However, there has been a lack of …

The canonical model for G protein-coupled receptors (GPCRs) activation assumes that
stimulation of heterotrimeric G protein signaling upon ligand binding occurs solely at the cell …