Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …

Members of the seven-transmembrane receptor (7TMR), or G protein-coupled receptor
(GPCR), superfamily represent some of the most successful targets of modern drug therapy …

Stimulated CD4+ T lymphocytes can differentiate into effector T cell (Teff) or inducible
regulatory T cell (Treg) subsets with specific immunological roles. We show that Teff and …

Catecholamine-stimulated β2-adrenergic receptor (β2AR) signaling via the canonical Gs–
adenylyl cyclase–cAMP–PKA pathway regulates numerous physiological functions …

Asthma is a heterogeneous inflammatory disease of the airways that is associated with
airway hyperresponsiveness and airflow limitation. Although asthma was once simply …

Current therapy for asthma is highly effective. β 2-Adrenergic receptor (β 2 AR) agonists are
the most effective bronchodilators and relax airway smooth muscle cells through increased …

The β 2-adrenergic receptor (β 2 AR) is a prototypical G protein-coupled receptor that
mediates many hormonal responses, including cardiovascular and pulmonary function. β …

Arrestins are multifunctional proteins that regulate G-protein-coupled receptor (GPCR)
desensitization, signaling, and internalization. The arrestin family consists of four subtypes …

The mostly widely used bronchodilators in asthma therapy are β2-adrenoreceptor (β2AR)
agonists, but their chronic use causes paradoxical adverse effects. We have previously …

G protein-coupled receptor kinase type 2 (GRK2) and β-arrestin2 are representative proteins
that regulate the transduction and trafficking of G protein-coupled receptor (GPCR) …