Anti-diabetic drugs and weight loss in patients with type 2 diabetes

E Lazzaroni, MB Nasr, C Loretelli, I Pastore… - Pharmacological …, 2021 - Elsevier
Introduction Obesity is frequently a comorbidity of type 2 diabetes. Even modest weight loss
can significantly improve glucose homeostasis and lessen cardiometabolic risk factors in …

From glucose lowering agents to disease/diabetes modifying drugs: a “SIMPLE” approach for the treatment of type 2 diabetes

O Mosenzon, S Del Prato, M Schechter… - Cardiovascular …, 2021 - Springer
During the last decade we experienced a surge in the number of glucose lowering agents
that can be used to treat patients with type 2 diabetes. Especially important are the …

American Association of Clinical Endocrinology Consensus Statement: comprehensive type 2 diabetes management algorithm–2023 update

SL Samson, P Vellanki, L Blonde, EA Christofides… - Endocrine Practice, 2023 - Elsevier
Objective This consensus statement provides (1) visual guidance in concise graphic
algorithms to assist with clinical decision-making of health care professionals in the …

SGLT2-inhibitors are effective and safe in the elderly: The SOLD study

ME Lunati, V Cimino, A Gandolfi, M Trevisan… - Pharmacological …, 2022 - Elsevier
Background and aims Sodium-glucose co-transporter-2 inhibitors (SGLT2i) may have
important benefits for the elderly with type 2 diabetes (T2D), however some safety concerns …

Hypertension and type 2 diabetes—the novel treatment possibilities

A Przezak, W Bielka, A Pawlik - International Journal of Molecular …, 2022 - mdpi.com
Elevated blood pressure and hyperglycaemia frequently coexist and are both components of
metabolic syndrome. Enhanced cardiovascular risk is strongly associated with diabetes and …

Once‐weekly semaglutide use in patients with type 2 diabetes: real‐world data from the SURE Italy observational study

R Napoli, C Berra, AM Catarig… - Diabetes, Obesity …, 2023 - Wiley Online Library
Aims SURE Italy, a multicentre, prospective, open‐label, observational, real‐world study,
investigated once‐weekly semaglutide in patients with type 2 diabetes (T2D) in routine …

Cardiovascular effects of non-insulin glucose-lowering agents: a comprehensive review of trial evidence and potential cardioprotective mechanisms

G Savarese, J Butler, LH Lund, DL Bhatt… - Cardiovascular …, 2022 - academic.oup.com
Type 2 diabetes mellitus (T2DM) is highly prevalent and associated with a two-fold
increased mortality, mostly explained by cardiovascular diseases. Trial evidence on older …

From kidney protection to stroke prevention: the potential role of sodium glucose cotransporter-2 inhibitors

CY Hsieh, SF Sung - International Journal of Molecular Sciences, 2022 - mdpi.com
Chronic kidney disease (CKD) is an independent risk factor for stroke and covert
cerebrovascular disease, and up to 40% of stroke patients have concomitant CKD. However …

Underuse of GLP-1 receptor agonists in the management of type 2 diabetes despite a favorable benefit-safety profile

AJ Scheen - Expert Opinion on Drug Safety, 2024 - Taylor & Francis
Introduction Patients with type 2 diabetes (T2DM) are at high risk of atherosclerotic
cardiovascular disease (ASCVD) and cardiovascular death. Cardiovascular protection is a …

Dapagliflozin acutely improves kidney function in type 2 diabetes mellitus. The PRECARE study

E Lazzaroni, ME Lunati, L Montefusco, I Pastore… - Pharmacological …, 2022 - Elsevier
Dapagliflozin has been demonstrated to improve glycemic control, blood pressure, and body
weight in type 2 diabetes mellitus (T2D); indeed, it can also reduce the risk of progression to …