Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the
intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene …

Gut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate …

Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within
minutes after eating. One of their many physiological roles is to regulate the amount of …

Mammalian studies have shaped our understanding of the endocrine control of appetite and
body weight in vertebrates and provided the basic vertebrate model that involves central …

A large body of research has been dedicated to the effects of gastrointestinal peptides on
vagal afferent fibres, yet multiple lines of evidence indicate that gastrointestinal peptides …

Abstract Glucagon-like peptide 1 (GLP-1) is a cleavage product of the pre-proglucagon gene
which is expressed in the α-cells of the pancreas, the L-cells of the intestine, and neurons …

To elucidate the causes of the diminished incretin effect in type 2 diabetes mellitus we
investigated the secretion of the incretin hormones, glucagon-like peptide-1 and glucose …

Glucagon-Like Peptides | Endocrine Reviews | Oxford Academic Skip to Main Content
Advertisement Oxford Academic Journals Books Search Menu Information Account Menu …

Nutrient stimulation of enteroendocrine L cells induces the release of the incretin and
satiating peptide glucagon-like peptide 1 (GLP-1). The vagus nerve innervates visceral …

Despite significant progress in understanding the homeostatic regulation of energy balance,
successful therapeutic options for curbing obesity remain elusive. One potential target for the …