Glucagon-like peptide-1-(7–36) amide is transformed to glucagon-like peptide-1-(9–36) amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the …
L Hansen, CF Deacon, C Ørskov, JJ Holst - Endocrinology, 1999 - academic.oup.com
The insulinotropic hormone glucagon-like peptide-1 (GLP-1) is stored in the intestinal L cell
in an active form, GLP-1-(7–36) amide, but more than half of the endogenous peptide …
in an active form, GLP-1-(7–36) amide, but more than half of the endogenous peptide …
[HTML][HTML] Peptides and food intake
C Sobrino Crespo, A Perianes Cachero… - Frontiers in …, 2014 - frontiersin.org
The mechanisms for controlling food intake involve mainly an interplay between gut, brain,
and adipose tissue (AT), among the major organs. Parasympathetic, sympathetic, and other …
and adipose tissue (AT), among the major organs. Parasympathetic, sympathetic, and other …
The inhibitory effects of peripheral administration of peptide YY3–36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal–brainstem …
CR Abbott, M Monteiro, CJ Small, A Sajedi, KL Smith… - Brain research, 2005 - Elsevier
The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract and the
brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require …
brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require …
Enhancing incretin action for the treatment of type 2 diabetes
DJ Drucker - Diabetes care, 2003 - Am Diabetes Assoc
OBJECTIVE—To examine the mechanisms of action, therapeutic potential, and challenges
inherent in the use of incretin peptides and dipeptidyl peptidase-IV (DPP-IV) inhibitors for the …
inherent in the use of incretin peptides and dipeptidyl peptidase-IV (DPP-IV) inhibitors for the …
Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4
The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonists, exendin-4 and
liraglutide, suppress food intake and body weight. The mediating site (s) of action for the …
liraglutide, suppress food intake and body weight. The mediating site (s) of action for the …
[HTML][HTML] Microbiota-gut-brain axis: Relationships among the vagus nerve, gut microbiota, obesity, and diabetes
S Longo, S Rizza, M Federici - Acta diabetologica, 2023 - Springer
Aims The purpose of this review is to explore the interconnected pathways of the microbiota-
gut-brain axis (MGBA), focusing on the roles of the vagus nerve and glucagon like peptide-1 …
gut-brain axis (MGBA), focusing on the roles of the vagus nerve and glucagon like peptide-1 …
Effects of GLP-1 and its analogs on gastric physiology in diabetes mellitus and obesity
DB Maselli, M Camilleri - Diabetes: from Research to Clinical Practice …, 2021 - Springer
The processing of proglucagon in intestinal L cells results in the formation of glucagon, GLP-
1, and GLP-2. The GLP-1 molecule becomes active through the effect of proconvertase 1 …
1, and GLP-2. The GLP-1 molecule becomes active through the effect of proconvertase 1 …
Biological actions and therapeutic potential of the glucagon-like peptides
DJ Drucker - Gastroenterology, 2002 - Elsevier
The glucagon-like peptides (GLP-1 and GLP-2) are proglucagon-derived peptides
cosecreted from gut endocrine cells in response to nutrient ingestion. GLP-1 acts as an …
cosecreted from gut endocrine cells in response to nutrient ingestion. GLP-1 acts as an …
Obesity: a review of pathophysiology and classification
Obesity is a chronic, multifactorial, and morbid disease. In the United States, 69% of adults
are overweight or have obesity, and the global prevalence of obesity is increasing. Obesity …
are overweight or have obesity, and the global prevalence of obesity is increasing. Obesity …
Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure
L Rinaman - Brain research, 2010 - Elsevier
Metabolic homeostasis reflects the complex output of endocrine, autonomic, and behavioral
control circuits that extend throughout the central nervous system. Brain regions that control …
control circuits that extend throughout the central nervous system. Brain regions that control …