Glucagon‐like peptide 1 (GLP‐1) in biology and pathology

JJ Meier, MA Nauck - Diabetes/metabolism research and …, 2005 - Wiley Online Library
Post‐translational proteolytic processing of the preproglucagon gene in the gut results in the
formation of glucagon‐like peptide 1 (GLP‐1). Owing to its glucose‐dependent …

Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia

AM Deane, NQ Nguyen, JE Stevens… - The Journal of …, 2010 - academic.oup.com
Introduction: The role of glucagon-like peptide-1 (GLP-1) in the regulation of gastric
emptying is uncertain. The aim of this study was to determine the effects of endogenous GLP …

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain

KM Heppner, M Kirigiti, A Secher, SJ Paulsen… - …, 2015 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) is released from endocrine L-cells lining the gut in
response to food ingestion. However, GLP-1 is also produced in the nucleus of the solitary …

The role of the gut/brain axis in modulating food intake

AH Sam, RC Troke, TM Tan, GA Bewick - Neuropharmacology, 2012 - Elsevier
Peptide hormones released from the gastrointestinal tract communicate information about
the current state of energy balance to the brain. These hormones regulate appetite and …

Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans

J Schirra, M Nicolaus, R Roggel, M Katschinski, M Storr… - Gut, 2006 - gut.bmj.com
Background: Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1)
lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric …

The physiology of gastric emptying

PM Hellström, P Grybäck, H Jacobsson - Best Practice & Research Clinical …, 2006 - Elsevier
The gastric emptying rate is a carefully regulated process consisting of different
mathematically defined phases. The gastric metabolic load, as well as neural regulatory …

Glucagon-like peptide-1: glucose homeostasis and beyond

YM Cho, Y Fujita, TJ Kieffer - Annual review of physiology, 2014 - annualreviews.org
Glucagon-like peptide-1 (GLP-1), an incretin hormone secreted primarily from the intestinal
L-cells in response to meals, modulates nutrient homeostasis via actions exerted in multiple …

The novel dual glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 (GLP‐1) receptor agonist tirzepatide transiently delays gastric emptying …

S Urva, T Coskun, C Loghin, X Cui… - Diabetes, Obesity …, 2020 - Wiley Online Library
The effect of dual glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like
peptide‐1 (GLP‐1) receptor agonist (RA) tirzepatide on gastric emptying (GE) was …

Effect of exenatide on gastric emptying and relationship to postprandial glycemia in type 2 diabetes

H Linnebjerg, S Park, PA Kothare, ME Trautmann… - Regulatory peptides, 2008 - Elsevier
OBJECTIVES: To evaluate the effect of exenatide on gastric emptying (GE) in type 2
diabetes using scintigraphy. METHODS: Seventeen subjects with type 2 diabetes …

GLP-1: Molecular mechanisms and outcomes of a complex signaling system

NK Smith, TA Hackett, A Galli, CR Flynn - Neurochemistry international, 2019 - Elsevier
Meal ingestion provokes the release of hormones and transmitters, which in turn regulate
energy homeostasis and feeding behavior. One such hormone, glucagon-like peptide-1 …