Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice
Glucagon-like peptide-1 (GLP-1) circulates at low levels and acts as an incretin hormone,
potentiating glucose-dependent insulin secretion from islet β cells. GLP-1 also modulates …
potentiating glucose-dependent insulin secretion from islet β cells. GLP-1 also modulates …
Effects of intravenous glucagon-like peptide-1 on gastric emptying and intragastric distribution in healthy subjects: relationships with postprandial glycemic and …
TJ Little, AN Pilichiewicz, A Russo… - The Journal of …, 2006 - academic.oup.com
Context: The inhibitory action of glucagon-like peptide-1 (GLP-1) on gastric emptying (GE) is
likely to be important in mediating its effects on postprandial glycemia, appetite, and …
likely to be important in mediating its effects on postprandial glycemia, appetite, and …
Efficacy and safety of tirzepatide, dual GLP-1/GIP receptor agonists, in the management of type 2 diabetes: a systematic review and meta-analysis of randomized …
Q Zhou, X Lei, S Fu, P Liu, C Long, Y Wang, Z Li… - Diabetology & Metabolic …, 2023 - Springer
Background Glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 are the main
incretin hormones, and be responsible for the insulinotropic incretin effect. The addition of a …
incretin hormones, and be responsible for the insulinotropic incretin effect. The addition of a …
Gastric inhibitory polypeptide: the neglected incretin revisited
JJ Meier, MA Nauck, WE Schmidt, B Gallwitz - Regulatory peptides, 2002 - Elsevier
After the ingestion of fat-and glucose-rich meals, gut hormones are secreted into the
circulation in order to stimulate insulin secretion. This so-called “incretin effect” is primarily …
circulation in order to stimulate insulin secretion. This so-called “incretin effect” is primarily …
The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty
A Plamboeck, S Veedfald, CF Deacon… - American Journal …, 2013 - journals.physiology.org
Rapid degradation of glucagon-like peptide-1 (GLP-1) by dipeptidyl peptidase-4 suggests
that endogenous GLP-1 may act locally before being degraded. Signaling via the vagus …
that endogenous GLP-1 may act locally before being degraded. Signaling via the vagus …
The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1
SM Fortin, JC Chen, MC Petticord, FJ Ragozzino… - Science …, 2023 - science.org
Increasing the therapeutic potential and reducing the side effects of US Food and Drug
Administration–approved glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat …
Administration–approved glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat …
Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 …
The effects of peripheral glucagon like peptide-1 receptor (GLP-1R) stimulation on feeding,
gastric emptying, and energetic responses involve vagal transmission and central nervous …
gastric emptying, and energetic responses involve vagal transmission and central nervous …
GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice
T Hansotia, DJ Drucker - Regulatory peptides, 2005 - Elsevier
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
are gut-derived incretins secreted in response to nutrient ingestion. Both incretins potentiate …
are gut-derived incretins secreted in response to nutrient ingestion. Both incretins potentiate …
Role of the glucagon-like-peptide-1 receptor in the control of energy balance
The peripheral and central glucagon-like-peptide-1 (GLP-1) systems play an essential role
in glycemic and energy balance regulation. Thus, pharmacological targeting of peripheral …
in glycemic and energy balance regulation. Thus, pharmacological targeting of peripheral …
The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake
For humans and animal models alike there is general agreement that the central nervous
system processing of gastrointestinal (GI) signals arising from ingested food provides the …
system processing of gastrointestinal (GI) signals arising from ingested food provides the …