Gastric emptying is a critical regulator of postprandial glucose and delayed gastric emptying
is an important mechanism of improved glycemic control achieved by short-acting glucagon …

The pre-proglucagon derived peptides, glucagon-like peptide-1 (GLP-1) and glucagon-like
peptide-2 (GLP-2) are both involved in a wide variety of peripheral functions, such as …

Glucagon-like peptide (GLP)-1 inhibits acid secretion and gastric emptying in humans, but
the effect on acid secretion is lost after vagotomy. To elucidate the mechanism involved, we …

The prevalence of obesity continues to grow rapidly worldwide, posing many public health
challenges of the 21st century. Obese subjects are at major risk for serious diet-related …

Aims/hypothesis This study was designed to ascertain whether human enteroendocrine
cells express bitter taste receptors, and whether activation of these receptors with bitter …

Here, we provide a focused review of the evidence for the roles of the vagus nerve in
mediating the regulatory effects of peripherally and centrally produced GLP‐1 on eating …

Background Recent advancements in understanding the roles and functions of glucagon‐
like peptide 1 (GLP‐1) and 2 (GLP‐2) have provided a basis for targeting these peptides in …

Abstract Glucagon-like peptide 1 (GLP-1) is a multifunctional hormone in glucose
metabolism and intestinal function released by enteroendocrine L-cells. The plasma …

Previous work from our lab has demonstrated that experience with high-intensity sweeteners
in rats leads to increased food intake, body weight gain and adiposity, along with diminished …

The worldwide increase in the incidence of obesity is a consequence of a positive energy
balance, with energy intake exceeding expenditure. The signalling systems that underlie …