Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

N Vrang, PJ Larsen - Progress in neurobiology, 2010 - Elsevier
The scientific understanding of preproglucagon derived peptides has provided people with
type 2 diabetes with two novel classes of glucose lowering agents, the dipeptidyl peptidase …

The enteroinsular axis and the recovery from type 2 diabetes after bariatric surgery

A Patriti, E Facchiano, A Sanna, N Gullà, A Donini - Obesity surgery, 2004 - Springer
The Roux-en-Y gastric bypass (RYGBP) and the biliopancreatic diversion (BPD) induce long-
term control of type 2 diabetes in morbidly obese individuals. The reasons for such an effect …

Using a reporter mouse to map known and novel sites of GLP-1 receptor expression in peripheral tissues of male mice

DB Andersen, KV Grunddal, J Pedersen… - …, 2021 - academic.oup.com
Abstract Glucagon-like peptide-1 receptor (GLP-1R) activation is used in the treatment of
diabetes and obesity; however, GLP-1 induces many other physiological effects with unclear …

The physiological role of GLP-1 in human: incretin, ileal brake or more?

J Schirra, B Göke - Regulatory peptides, 2005 - Elsevier
The proglucagon-derived peptide glucagon-like peptide-1 (GLP-1) is an intestinal signal
peptide postprandially released from the L cells of the lower gut. Exogenously administered …

GLP‐1 based therapies: differential effects on fasting and postprandial glucose

MS Fineman, BB Cirincione, D Maggs… - Diabetes, Obesity and …, 2012 - Wiley Online Library
Glucagon‐like peptide‐1 (GLP‐1), a gut‐derived hormone secreted in response to nutrients,
has several glucose and weight regulating actions including enhancement of glucose …

An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis

LL Baggio, Q Huang, X Cao, DJ Drucker - Gastroenterology, 2008 - Elsevier
Background & Aims: Glucagon-like peptide-1 (GLP-1) regulates glucose homeostasis
through multiple mechanisms including direct actions on the endocrine pancreas and …

[HTML][HTML] Control of food intake by gastrointestinal peptides: mechanisms of action and possible modulation in the treatment of obesity

P Prinz, A Stengel - Journal of Neurogastroenterology and Motility, 2017 - ncbi.nlm.nih.gov
This review focuses on the control of appetite by food intake-regulatory peptides secreted
from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY …

[HTML][HTML] Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output

J Liu, K Yang, J Yang, W Xiao, Y Le, F Yu, L Gu… - …, 2019 - thelancet.com
Abstract Background Glucagon-like peptide-1 (GLP-1) and its based agents improve
glycemic control. Although their attenuating effect on hepatic glucose output has drawn our …

Antidiabetic drugs: mechanisms of action and potential outcomes on cellular metabolism

MJ Meneses, BM Silva, M Sousa, R Sá… - Current …, 2015 - ingentaconnect.com
Diabetes mellitus (DM) is one of the most prevalent chronic diseases and has been a
leading cause of death in the last decades. Thus, methods to detect, prevent or delay this …

Therapy of type 2 diabetes mellitus based on the actions of glucagon‐like peptide‐1

JJ Holst - Diabetes/metabolism research and reviews, 2002 - Wiley Online Library
GLP‐1 is a peptide hormone from the intestinal mucosa. It is secreted in response to meal
ingestion and normally functions in the so‐called ileal brake, that is, inhibition of upper …