Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

The development of increasingly biomimetic human tissue analogs has been a long-
standing goal in two important biomedical applications: drug discovery and regenerative …

The vascularization of engineered tissues and organoids has remained a major unresolved
challenge in regenerative medicine. While multiple approaches have been developed to …

Three-dimensional multicellular tumor models are receiving an ever-growing focus as
preclinical drug-screening platforms due to their potential to recapitulate major physiological …

The specific microenvironment that cells reside in fundamentally impacts their broader
function in tissues and organs. At its core, this microenvironment is composed of precise …

Simple Summary Colorectal cancer is one of the most common solid tumors in the
developed world. Although there have being many advances in treatment options in recent …

Two-dimensional (2D) cell cultures have been the standard for many different applications,
ranging from basic research to stem cell and cancer research to regenerative medicine, for …

Introduction: Despite the increasing financial outlay on cancer research and drug discovery,
many advanced cancers remain incurable. One possible strategy for increasing the approval …

In vitro 3D culture systems provide promising tools for screening novel therapies and
understanding drug resistance mechanisms in cancer because they are adapted for high …

Lung cancer is the leading cause of cancer-related death worldwide, yet in vitro disease
models have been limited to traditional 2D culture utilizing cancer cell lines. In contrast …