The mechanisms which contribute to the actions of atypical antipsychotic drugs, such as
clozapine and the putative atypical agents remoxipride and raclopride, are reviewed …

Male rats housed in mixed-sex groups quickly established dominance hierarchies in which
subordinates appeared severely stressed. Subordinate rats had elevated basal …

Quantitative autoradiography was used to evaluate the effects of adrenalectomy (ADX) and
corticosterone (CORT) on binding at 5-HT1A and 5-HT1B receptors in the dorsal …

The density of [125I] iodo‐cyanopindolol binding to beta‐1 and beta‐2 adrenergic receptors
was studied in post mortem basal ganglia samples of Huntington's chorea and Parkinson's …

In this study, we compared the localization of central 5-HT 1 binding sites of rat and guinea
pig. The 5-HT 1B sites were absent in the guinea pig brain. Good correlations were found …

Abstract: 3‐(1, 2, 5, 6‐Tetrahydro‐4‐pyridyl)‐5‐n‐propoxyindole (CP‐96,501) was found to
be a more selective ligand at the serotonin 5‐HT1B receptor than the commonly used 5 …

Abstract While serotonin (5-HT) has been shown to be anticonvulsant in several types of
experimentally induced seizures, 5-HT receptor binding has not been investigated in the …

Abstract 3‐(1, 2, 5, 6‐Tetrahydro‐4‐pyridyl)‐5‐pyrrolo [3, 2‐b] pyridone, CP‐93, 129, is a
selective agonist ligand for 5‐HT1B receptors. High affinity binding sites of [3H] CP‐93, 129 …

Receptor-mediated signal transduction requires interaction between receptor, G-protein,
and effector. Agonist binding to receptor stabilizes a high affinity ternary complex, HRG …

This unit describes assays for measuring the binding of radioligands to two major types of
receptors for 5‐hydroxytryptamine (5‐HT or serotonin), 5‐HT1 and 5‐HT2 receptors, in …