Our understanding of the ubiquitin code has greatly evolved from conventional E1, E2 and
E3 enzymes that modify Lys residues on specific substrates with a single type of ubiquitin …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) are the family of vital lipid kinases widely
distributed in mammalian cells. The overexpression of PI3Ks leads to hyperactivation of the …

The activation of the cyclic GMP-AMP synthase-stimulator of interferon gene (STING)
pathway has been associated with the pathogenesis of many autoimmune and inflammatory …

Histone deacetylase 6 (HDAC6) is a potential therapeutic target for treating several
diseases. A recent study revealed that HDAC6 is important for NLRP3 inflammasome …

Targeted protein degradation using proteolysis-targeting chimeras (PROTACs) has
emerged as an effective strategy for drug discovery, given their unique advantages over …

Recent advances in understanding the tumor's biology in line with a constantly growing
number of innovative technologies have prompted characterization of patients' individual …

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with
insufficient options for therapy. In order to identify new targets and treatment modalities we …

Precision oncology benefits from effective early phase drug discovery decisions. Recently,
drugging inactive protein conformations has shown impressive successes, raising the …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for about
672 million infections and 6.85 million deaths worldwide. Upon SARS-CoV-2 infection …

Proteolysis targeting chimeras (PROTACs) are bifunctional degrader molecules via
hijacking the ubiquitin-proteasome system (UPS) to specifically eliminate targeted proteins …