The epithelial mesenchymal transition (EMT) plays a central role in both normal
physiological events (eg, embryonic development) and abnormal pathological events (eg …

Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

Therapy resistance arises from heterogeneous drug-tolerant persister cells or minimal
residual disease (MRD) through genetic and nongenetic mechanisms. A key question is …

Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for
preclinical studies and therapeutic testing. It has been proposed that the mouse host affects …

Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous
macromolecular networks on a proteome scale, but current methods are experimentally …

Focal adhesion kinase (FAK, also known as PTK2) is a tyrosine kinase that regulates
integrin and growth factor signaling pathways and is involved in the migration, proliferation …

Focal adhesion kinase (FAK) is a nonreceptor intracellular tyrosine kinase that plays an
essential role in cancer cell adhesion, survival, proliferation, and migration through both its …

Although cancer stem cells have been well characterized in numerous malignancies, the
fundamental characteristics of this group of cells, however, have been challenged by some …

FAK is a nonreceptor intracellular tyrosine kinase which plays an important biological
function. Many studies have found that FAK is overexpressed in many human cancer cell …

Cancer resistance to therapy is a big issue in cancer therapy. Tumours may develop some
mechanisms to reduce the induction of cell death, thus stimulating tumour growth. Cancer …