Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …

Cancer resistance to therapy is a big issue in cancer therapy. Tumours may develop some
mechanisms to reduce the induction of cell death, thus stimulating tumour growth. Cancer …

Triple-negative breast cancer (TNBC) is an aggressive breast tumor subtype that currently
lacks targeted treatment options. The role played by the insulin-like growth factor-1 (IGF-1) …

Background Focal adhesion kinase (FAK) is a cytoplasmatic protein tyrosine kinase that
associates with both integrins and growth factor receptors toward the adhesion, migration …

Integrins are cell-matrix adhesion molecules providing both mechanical engagement of cell
to extracellular matrix, and generation of cellular signals that are implicated in cancer …

Cancer is a major health burden worldwide. Despite the advances in our understanding of
its pathogenesis and continued improvement in cancer management and outcomes, there …

Hyaluronic acid (HA), also named hyaluronan, is an omnipresent component of the tissue
microenvironment. It is extensively used to formulate targeted drug delivery systems for …

Breast cancer is one of the most prevalent cancers in women contributing to cancer-related
death in the advanced world. Apart from the menopausal status, the trigger for developing …

As one of the life-threatening diseases involving multi-step genetic and epigenetic disorders,
cancer has long been a dynamic research area for siRNA-based therapy as half of the …

Gastric cancer (GC) is one of the most frequent malignant tumors worldwide and is
associated with high invasiveness, high metastasis and poor prognosis. Cancer‐associated …