Resveratrol, a safe and multi-targeted agent, has been associated with suppression of
survival, proliferation and metastasis of cancer, however, the underlying mechanisms for its …

Leptin is one of the main adipokines secreted in breast tissue. Leptin promotes epithelial–
mesenchymal transition (EMT), cell migration and invasion in epithelial breast cells, leading …

Focal adhesion kinase (FAK) and its close paralogue, proline-rich tyrosine kinase 2 (PYK2),
are key regulators of aggressive spreading and metastasis of cancer cells. While targeted …

Background Although the study of calcium (Ca 2+) is classically associated with excitable
cells such as myocytes or neurons, the ubiquity of this essential element in all cellular …

Breast cancer is the most common invasive neoplasia, and the second leading cause of the
cancer deaths in women worldwide. Mammary tumorigenesis is severely linked to obesity …

The partner of activated epidermal growth factor receptor (EGFR), growth factor receptor
bound protein-7 (Grb7), a functionally multidomain adaptor protein, has been demonstrated …

Keratin8 (KRT 8) is the major component of the intermediate filament cytoskeleton and
predominantly expressed in simple epithelial tissues. Aberrant expression of KRT 8 is …

Metastatic prostate cancer spreads preferentially to the bone, causing skeletal complications
associated with significant morbidity and a poor prognosis, despite current therapeutic …

The mucosal surfaces of fish play numerous roles including, but not limited to, protection
against pathogens, nutrient digestion and absorption, excretion of nitrogenous wastes and …

Abstract Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively
associated with highly curved and prominent membrane structures. It is widely recognized …