Background: Breast cancer (BC) is the second most common cancer overall. In women, BC
is the most prevalent cancer and the leading cause of cancer-related mortality. Triple …

More aggressive and therapy-resistant oestrogen receptor (ER)-positive breast cancers
remain a great clinical challenge. Here our integrative genomic analysis identifies tousled …

As cancers are one of the most important causes of human morbidity and mortality
worldwide, researchers try to discover novel compounds and therapeutic approaches to …

Chondrosarcoma is the second most common primary malignancy of bone after myeloma
and osteosarcoma. Chondrosarcoma development may be linked to angiogenesis, which is …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death
worldwide. Due to the high incidence of post-operative recurrence after current treatments …

The Insulin-like growth factor (IGF) axis is one of the best-established drivers of thyroid
transformation, as thyroid cancer cells overexpress both IGF ligands and their receptors …

Purpose Previous study reported that Piezo1 was highly expressed in glioma and promoted
the proliferation of glioma cells, suggesting that Piezo1 overexpression might contribute to …

Hypertrophic scarring is a fibrotic skin disease characterized by excessive deposition of
collagens. Emerging evidence has suggested important roles for peptides in fibrosis-related …

Background Overexpression/activation of focal adhesion kinase (FAK) in human
malignancies has led to its evaluation as a therapeutic target. We report the first-in-human …

Oral squamous cell carcinoma (OSCC) accounts for about 90% of all head and neck
cancers, the prognosis is very poor, and there are no effective targeted therapies. Herein, we …