Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties
J Mesmar, R Abdallah, K Hamade… - Frontiers in …, 2022 - frontiersin.org
Background: Breast cancer (BC) is the second most common cancer overall. In women, BC
is the most prevalent cancer and the leading cause of cancer-related mortality. Triple …
is the most prevalent cancer and the leading cause of cancer-related mortality. Triple …
Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
More aggressive and therapy-resistant oestrogen receptor (ER)-positive breast cancers
remain a great clinical challenge. Here our integrative genomic analysis identifies tousled …
remain a great clinical challenge. Here our integrative genomic analysis identifies tousled …
Flavonoid-based cancer therapy: an updated review
E Hosseinzadeh, A Hassanzadeh… - Anti-Cancer Agents …, 2020 - ingentaconnect.com
As cancers are one of the most important causes of human morbidity and mortality
worldwide, researchers try to discover novel compounds and therapeutic approaches to …
worldwide, researchers try to discover novel compounds and therapeutic approaches to …
Amphiregulin enhances VEGF-A production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR-206 via FAK/c-Src/PKCδ pathway
Chondrosarcoma is the second most common primary malignancy of bone after myeloma
and osteosarcoma. Chondrosarcoma development may be linked to angiogenesis, which is …
and osteosarcoma. Chondrosarcoma development may be linked to angiogenesis, which is …
Focal adhesion kinase: insight into molecular roles and functions in hepatocellular carcinoma
N Panera, A Crudele, I Romito, D Gnani… - International journal of …, 2017 - mdpi.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death
worldwide. Due to the high incidence of post-operative recurrence after current treatments …
worldwide. Due to the high incidence of post-operative recurrence after current treatments …
Activation of the IGF axis in thyroid cancer: implications for tumorigenesis and treatment
L Manzella, M Massimino, S Stella, E Tirrò… - International journal of …, 2019 - mdpi.com
The Insulin-like growth factor (IGF) axis is one of the best-established drivers of thyroid
transformation, as thyroid cancer cells overexpress both IGF ligands and their receptors …
transformation, as thyroid cancer cells overexpress both IGF ligands and their receptors …
Upregulation of Piezo1 is a novel prognostic indicator in glioma patients
S Qu, S Li, Z Hu - Cancer Management and Research, 2020 - Taylor & Francis
Purpose Previous study reported that Piezo1 was highly expressed in glioma and promoted
the proliferation of glioma cells, suggesting that Piezo1 overexpression might contribute to …
the proliferation of glioma cells, suggesting that Piezo1 overexpression might contribute to …
[HTML][HTML] Peptide deregulated in hypertrophic scar-1 alleviates hypertrophic scar fibrosis by targeting focal adhesion kinase and pyruvate kinase M2 and remodeling …
J Li, Y Yin, E Zhang, M Gui, L Chen, J Li - International Journal of Biological …, 2023 - Elsevier
Hypertrophic scarring is a fibrotic skin disease characterized by excessive deposition of
collagens. Emerging evidence has suggested important roles for peptides in fibrosis-related …
collagens. Emerging evidence has suggested important roles for peptides in fibrosis-related …
Phase I study of BI 853520, an inhibitor of focal adhesion kinase, in patients with advanced or metastatic nonhematologic malignancies
Background Overexpression/activation of focal adhesion kinase (FAK) in human
malignancies has led to its evaluation as a therapeutic target. We report the first-in-human …
malignancies has led to its evaluation as a therapeutic target. We report the first-in-human …
Machilin D Promotes Apoptosis and Autophagy, and Inhibits Necroptosis in Human Oral Squamous Cell Carcinoma Cells
HM Yun, YJ Kwon, E Kim, HJ Chung… - International Journal of …, 2023 - mdpi.com
Oral squamous cell carcinoma (OSCC) accounts for about 90% of all head and neck
cancers, the prognosis is very poor, and there are no effective targeted therapies. Herein, we …
cancers, the prognosis is very poor, and there are no effective targeted therapies. Herein, we …