Immunomodulatory Yersinia outer proteins (Yops)–useful tools for bacteria and humans alike

B Grabowski, MA Schmidt, C Rüter - Virulence, 2017 - Taylor & Francis
Human-pathogenic Yersinia produce plasmid-encoded Yersinia outer proteins (Yops),
which are necessary to down-regulate anti-bacterial responses that constrict bacterial …

Epidermal growth factor receptor-mediated regulation of matrix metalloproteinase-2 and matrix metalloproteinase-9 in MCF-7 breast cancer cells

A Majumder, S Ray, A Banerji - Molecular and Cellular Biochemistry, 2019 - Springer
In breast cancer, increased epidermal growth factor receptor (EGFR) expression and
phosphorylation have been correlated with increased invasive potential and poor prognosis …

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling

A Merhi, P Delrée, AM Marini - Scientific reports, 2017 - nature.com
Two structurally and functionally distinct mammalian TOR complexes control cell growth and
metabolism in physiological and pathological contexts including cancer. Upregulated …

Matrix metalloproteinases in head and neck cancer: current perspectives

I Gkouveris, NG Nikitakis, J Aseervatham… - Metalloproteinases In …, 2017 - Taylor & Francis
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases encoded by 24
distinct genes. Their functions have been implicated in numerous normal and pathologic …

Functionalization, characterization and microbiological performance of new biocompatible cellulosic dressing grafted chitosan and Suaeda fruticosa polysaccharide …

FM Alminderej, C Ammar, Y El-Ghoul - Cellulose, 2021 - Springer
Nowadays, functional and entirely natural dressing treated with biological active polymers is
a required alternative to treat chronic or acute wounds. First, a Suaeda fruticosa …

Truncated O-Glycan-Bearing MUC16 enhances pancreatic cancer cells aggressiveness via α4β1 integrin complexes and FAK signaling

C Rajesh, S Sagar, AK Rathinavel… - International journal of …, 2022 - mdpi.com
Elevated levels of Mucin-16 (MUC16) in conjunction with a high expression of truncated O-
glycans is implicated in playing crucial roles in the malignancy of pancreatic ductal …

Latifolin, a Natural Flavonoid, Isolated from the Heartwood of Dalbergia odorifera Induces Bioactivities through Apoptosis, Autophagy, and Necroptosis in Human Oral …

HM Yun, JE Park, JY Lee, KR Park - International Journal of Molecular …, 2022 - mdpi.com
Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm with
frequent metastasis and high mortality in the oral cavity. Plant-derived natural compounds …

PRKAR1B-AS2 long noncoding RNA promotes tumorigenesis, survival, and chemoresistance via the PI3K/AKT/mTOR pathway

AM Elsayed, E Bayraktar, P Amero, SA Salama… - International journal of …, 2021 - mdpi.com
Many long noncoding RNAs have been implicated in tumorigenesis and chemoresistance;
however, the underlying mechanisms are not well understood. We investigated the role of …

The role of ECM remodeling, EMT, and adhesion molecules in cancerous neural invasion: changing perspectives

A Mukherjee, P Ha, KC Wai, S Naara - Advanced Biology, 2022 - Wiley Online Library
Perineural invasion (PNI) refers to the cancerous invasion of nerves. It provides an
alternative route for metastatic invasion and can exist independently in the absence of …

FAK is required for tumor metastasis-related fluid microenvironment in triple-negative breast cancer

MR Pan, MF Hou, F Ou-Yang, CC Wu… - Journal of clinical …, 2019 - mdpi.com
Cancer cell metastasis is the main cause of death in patients with cancer. Many studies have
investigated the biochemical factors that affect metastasis; however, the role of physical …