Vanadium complexes were studied during recent years and considered as a representative
of a new class of non-platinum metal antitumor agents in combination with their low toxicity …

Angelica keiskei Koidzumi (A. keiskei) is used as a traditional medicine, anti-aging agent,
and health food, as well as to restore vitality. Xanthoangelol (xanol), a prenylated chalcone …

目的: 观察藤龙补中汤对人大肠癌LoVo 细胞失巢凋亡的作用及机制. 方法: 将藤龙补中汤作用于
悬浮生长的LoVo 细胞, CCK-8 试剂检测细胞增殖; 试剂盒检测失巢凋亡, Caspases …

Molecular targeted therapy of advanced neuroendocrine tumours (NETs) of the
gastroenteropancreatic (GEP) system currently encompasses approved therapy with the …

Motivation The growth and survival of myeloma cells are greatly affected by their
surrounding microenvironment. To understand the molecular mechanism and the impact of …

A new class of pyrimidine derivatives were designed and synthesized as potential dual FAK
and EGFR T790M inhibitors using a fragment-based drug design strategy. This effort led to …

Peptidases are emerging as promising drug targets in tumour suppression. Neprilysin, also
known as neutral endopeptidase, is a cell surface peptidase that degrades various peptides …

Osteosarcoma, a common aggressive and malignant cancer, appears in the
musculoskeletal system among young adults. The major cause of mortality in osteosarcoma …

Inadequate responses to traditional chemotherapeutic agents in cholangiocarcinoma (CCA)
emphasize a requirement for new effective compounds for the treatment of this malignancy …

Abstract Doublecortin-like kinase 1 (DCLK1), a marker for intestinal and pancreatic cancer
stem cells, is highly expressed in neuroblastomas. This study was conducted to assess …